ctcRbase

Entry Detail

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General Information

Database ID: SKCM08606 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: LATS1 Full Name: large tumor suppressor kinase 1 Category: mRNA Synonyms: WARTS|wts Chromosome: chr6 Strand: - Coordinate: Start Site(bp): 149658153 End Site(bp): 149718256 Gene Summary: The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments. [provided by RefSeq, Apr 2017] External Links: Ensembl ID: ENSG00000131023 HGNC ID: HGNC:6514 Entrez Gene: 9113

Expression Profile of LATS1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-103a-3p YES YES YES hsa-miR-107 YES YES YES hsa-miR-10a-5p YES YES YES hsa-miR-10b-5p YES YES YES hsa-miR-135a-5p YES YES YES hsa-miR-135b-5p YES YES YES hsa-miR-153-3p YES YES NO hsa-miR-154-5p YES YES NO hsa-miR-15a-5p YES YES YES hsa-miR-15b-5p YES YES YES hsa-miR-16-5p YES YES YES hsa-miR-183-5p YES YES YES hsa-miR-195-5p YES YES YES hsa-miR-200b-3p YES YES NO hsa-miR-200c-3p YES YES NO hsa-miR-204-5p YES YES YES hsa-miR-211-5p YES YES YES hsa-miR-300 YES YES NO hsa-miR-330-3p YES NO YES hsa-miR-374a-5p YES YES YES hsa-miR-374b-5p YES YES YES hsa-miR-381-3p YES YES NO hsa-miR-424-5p YES YES YES hsa-miR-429 YES YES NO hsa-miR-495-3p YES YES NO hsa-miR-497-5p YES YES YES hsa-miR-543 YES YES NO hsa-miR-876-5p YES YES NO Display: