ctcRbase

Entry Detail

---



General Information

Database ID: SKCM08963 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: AMACR Full Name: alpha-methylacyl-CoA racemase Category: mRNA Synonyms: AMACRD|CBAS4|P504S|RACE|RM Chromosome: chr5 Strand: - Coordinate: Start Site(bp): 33986178 End Site(bp): 34008108 Gene Summary: This gene encodes a racemase. The encoded enzyme interconverts pristanoyl-CoA and C27-bile acylCoAs between their (R)- and (S)-stereoisomers. The conversion to the (S)-stereoisomers is necessary for degradation of these substrates by peroxisomal beta-oxidation. Encoded proteins from this locus localize to both mitochondria and peroxisomes. Mutations in this gene may be associated with adult-onset sensorimotor neuropathy, pigmentary retinopathy, and adrenomyeloneuropathy due to defects in bile acid synthesis. Alternatively spliced transcript variants have been described. Read-through transcription also exists between this gene and the upstream neighboring C1QTNF3 (C1q and tumor necrosis factor related protein 3) gene. [provided by RefSeq, Mar 2011] External Links: Ensembl ID: ENSG00000242110 HGNC ID: HGNC:451 Entrez Gene: 23600

Expression Profile of AMACR Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-1297 YES YES NO hsa-miR-204-5p YES YES YES hsa-miR-211-5p YES YES YES hsa-miR-216a-5p YES NO YES hsa-miR-216b-5p YES YES YES hsa-miR-26a-5p YES YES NO hsa-miR-26b-5p YES YES NO hsa-miR-377-3p YES YES YES hsa-miR-382-5p YES YES NO hsa-miR-433-3p YES YES NO hsa-miR-488-3p YES YES NO Display: