ctcRbase

Entry Detail

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General Information

Database ID: SKCM09137 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: TCF3 Full Name: transcription factor 3 Category: mRNA Synonyms: AGM8|E2A|E47|ITF1|TCF-3|VDIR|bHLHb21|p75 Chromosome: chr19 Strand: - Coordinate: Start Site(bp): 1609290 End Site(bp): 1652605 Gene Summary: This gene encodes a member of the E protein (class I) family of helix-loop-helix transcription factors. E proteins activate transcription by binding to regulatory E-box sequences on target genes as heterodimers or homodimers, and are inhibited by heterodimerization with inhibitor of DNA-binding (class IV) helix-loop-helix proteins. E proteins play a critical role in lymphopoiesis, and the encoded protein is required for B and T lymphocyte development. Deletion of this gene or diminished activity of the encoded protein may play a role in lymphoid malignancies. This gene is also involved in several chromosomal translocations that are associated with lymphoid malignancies including pre-B-cell acute lymphoblastic leukemia (t(1;19), with PBX1), childhood leukemia (t(19;19), with TFPT) and acute leukemia (t(12;19), with ZNF384). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, Sep 2011] External Links: Ensembl ID: ENSG00000071564 HGNC ID: HGNC:11633 Entrez Gene: 6929

Expression Profile of TCF3 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-103a-3p YES YES NO hsa-miR-107 YES YES NO hsa-miR-124-3p YES NO YES hsa-miR-137 YES YES YES hsa-miR-138-5p YES YES YES hsa-miR-139-5p YES YES YES hsa-miR-15a-5p YES YES YES hsa-miR-15b-5p YES YES YES hsa-miR-16-5p YES YES YES hsa-miR-190a-5p YES YES YES hsa-miR-190b YES YES YES hsa-miR-193a-5p YES NO YES hsa-miR-195-5p YES YES YES hsa-miR-214-3p YES NO NO hsa-miR-221-3p YES NO YES hsa-miR-222-3p YES NO YES hsa-miR-300 YES NO YES hsa-miR-365a-3p YES YES NO hsa-miR-381-3p YES NO YES hsa-miR-424-5p YES YES YES hsa-miR-497-5p YES YES YES hsa-miR-655-3p YES NO YES Display: