ctcRbase

Entry Detail

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General Information

Database ID: SKCM09268 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: SESN3 Full Name: sestrin 3 Category: mRNA Synonyms: SEST3 Chromosome: chr11 Strand: - Coordinate: Start Site(bp): 95165513 End Site(bp): 95232541 Gene Summary: This gene encodes a member of the sestrin family of stress-induced proteins. The encoded protein reduces the levels of intracellular reactive oxygen species induced by activated Ras downstream of RAC-alpha serine/threonine-protein kinase (Akt) and FoxO transcription factor. The protein is required for normal regulation of blood glucose, insulin resistance and plays a role in lipid storage in obesity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012] External Links: Ensembl ID: ENSG00000149212 HGNC ID: HGNC:23060 Entrez Gene: 143686

Expression Profile of SESN3 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-129-5p YES YES YES hsa-miR-130a-5p NO NO YES hsa-miR-142-3p YES YES NO hsa-miR-146a-5p YES YES NO hsa-miR-146b-5p YES YES NO hsa-miR-23a-3p NO NO YES hsa-miR-23b-3p NO NO YES hsa-miR-23c NO NO YES hsa-miR-25-3p YES YES YES hsa-miR-32-5p YES YES YES hsa-miR-363-3p YES YES YES hsa-miR-367-3p YES YES YES hsa-miR-383-5p YES YES NO hsa-miR-433-3p YES YES YES hsa-miR-488-3p YES YES NO hsa-miR-495-3p YES YES NO hsa-miR-520f-3p YES NO YES hsa-miR-92a-3p YES YES YES hsa-miR-92b-3p YES YES YES Display: