ctcRbase

Entry Detail

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General Information

Database ID: SKCM09313 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: MED1 Full Name: mediator complex subunit 1 Category: mRNA Synonyms: CRSP1|CRSP200|DRIP205|DRIP230|PBP|PPARBP|PPARGBP|RB18A|TRAP220|TRIP2 Chromosome: chr17 Strand: - Coordinate: Start Site(bp): 39404285 End Site(bp): 39451286 Gene Summary: The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. It also regulates p53-dependent apoptosis and it is essential for adipogenesis. This protein is known to have the ability to self-oligomerize. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000125686 HGNC ID: HGNC:9234 Entrez Gene: 5469

Expression Profile of MED1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-10a-5p YES YES NO hsa-miR-10b-5p YES YES NO hsa-miR-129-2-3p YES NO YES hsa-miR-137 YES YES YES hsa-miR-139-5p YES YES NO hsa-miR-1-3p YES YES YES hsa-miR-144-3p YES YES NO hsa-miR-149-5p YES YES NO hsa-miR-154-5p YES YES NO hsa-miR-15a-5p YES YES YES hsa-miR-15b-5p YES YES YES hsa-miR-16-5p YES YES YES hsa-miR-186-5p YES YES NO hsa-miR-195-5p YES YES YES hsa-miR-205-5p YES YES NO hsa-miR-206 YES YES YES hsa-miR-214-3p YES NO NO hsa-miR-224-5p YES YES NO hsa-miR-328-3p YES YES NO hsa-miR-335-5p YES YES NO hsa-miR-371a-5p YES YES NO hsa-miR-424-5p YES YES YES hsa-miR-433-3p YES YES YES hsa-miR-483-3p YES NO YES hsa-miR-488-3p YES YES NO hsa-miR-490-3p YES YES NO hsa-miR-494-3p YES YES NO hsa-miR-497-5p YES YES YES hsa-miR-532-5p YES NO YES hsa-miR-613 YES YES YES Display: