exRNAdisease

General Information

Database ID:

exR0006110

RNA Name:

GSTP1

RNA Type:

mRNA

Chromosome:

chr11

Starnd:

Coordinate:

Start Site(bp):

67583742

End Site(bp):

67586656

External Links:

Disease Information

Disease Name:	Down Syndrome
Disease Category:	Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH ID:	D004314
Type:	Diseases Category/Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Alias:	Syndrome, Down//Mongolism//47,XY,+21//Trisomy G//47,XX,+21//Down's Syndrome//Downs Syndrome//Syndrome, Down's//Trisomy 21//Trisomy 21, Mitotic Nondisjunction//Down Syndrome, Partial Trisomy 21//Partial Trisomy 21 Down Syndrome//Trisomy 21, Meiotic Nondisjunction

Expression Detail

GEO ID:	GSE16176
Description:	Expression profiles of amniotic fluid from human fetuses with Down syndrome and euploid controls
Experimental Design:	Disease vs Control
Case Disease Type:	Down Syndrome
Case Disease SubType:	NA
Case Sample:	Down Syndrome
Control Sample:	Normal
Number of Case:	7
Number of Control:	7
Number of Samples:	14

Regulatory Relationship

mRNA targets:

Gene Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
ADAM17	chr2	9488486	9556732	-
ACAD8	chr11	134253495	134265855	+
AC008982.1	chr19	38817471	38840178	-
ADCY7	chr16	50246137	50318135	+
AL035078.4	chr11	31812391	32104665	+
AL022238.4	chr22	40346529	40410054	+
ACTB	chr7	5527148	5563784	-
ACSF2	chr17	50426158	50474845	+
AC012184.2	chr16	70299194	70372582	+
ADRM1	chr20	62302093	62308862	+
ADCY3	chr2	24819169	24919839	-
AC010323.1	chr19	8308283	8321379	-
ACADVL	chr17	7217125	7225266	+
AC023055.1	chr12	55757275	55827546	-
ABCF3	chr3	184186023	184194012	+
ALDOA	chr16	30064164	30070457	+
ACTG1	chr17	81509971	81523847	-
ADGRL2	chr1	81306160	81992436	+
ABHD12	chr20	25294742	25390835	-
ABRAXAS2	chr10	124801819	124836667	+
AC004922.1	chr7	99325879	99394653	+
ACTR1B	chr2	97655939	97664044	-
AL132780.3	chr14	22946270	22982258	-
ADAR	chr1	154582057	154628013	-
AC010463.1	chr19	17267418	17282966	+
ACOT13	chr6	24667035	24705065	+
ACACA	chr17	37084992	37406836	-
ADSL	chr22	40346500	40390463	+
AC092073.1	chr19	34396315	34409364	+
ALDH1L1	chr3	126103562	126197994	-

miRNA targets:

miRNA Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
hsa-miR-23a-3p	chr19	13836595	13836615	-

circRNA targets:

lncRNA targets:

lncRNA Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
AC009446.1	chr8	71675300	71702786	+
AC016876.2	chr17	7581964	7584086	-
AC026362.1	chr12	122975320	122982907	+
AC139149.1	chr17	81514047	81527776	+
AD000090.1	chr19	35557956	35581954	+
AL138828.1	chr6	135991936	136225751	-

Display:

Experiment Detail

GEO ID:	GSE16176
Sample Source:	Amniotic Fluid
Source Fraction:	Supernatant
Platform:	GPL570
Method:	Microarray
Num of detected RNA Type:	1
Num of detected RNAs of this Type:	17063
Sample treatment protocol:	NA
RNA Extract protocol:	RNA was extracted from 10 mL AF with 30 mL TRIzol LS Reagent (Invitrogen, Carlsbad, CA) and 8 mL chloroform. After RNA extraction, RNA was purified and DNA was removed using the RNeasy® Maxi Kit, including the DNase step according to the manufacturer's protocol (QIAGEN, Valencia, CA). RNA was precipitated using 3M NaOAc and 100% ethanol, and 80% ethanol was added after 4 hours incubation at -20 °C. cDNA, synthesized from extracted RNA, was amplified and purified using the WT-Ovation™ Pico RNA Amplification System (NuGEN, San Carlos, CA) and the DNA Clean & Concentrator™-25 (Zymo Research, Orange, CA).
RNA library preparation protocol:	biotin Samples were labeled using the FL-Ovation™ cDNA Biotin Module V2 (NuGEN, San Carlos, CA).

Reference

PMID:	19474297
Title:	Functional genomic analysis of amniotic fluid cell-free mRNA suggests that oxidative stress is significant in Down syndrome fetuses
Author:	Slonim DK, Koide K, Johnson KL, Tantravahi U, Cowan JM, Jarrah Z, Bianchi DW
Journal:	Proc Natl Acad Sci U S A. 2009 Jun 9;106(23):9425-9.
Description:	To characterize the differences between second trimester Down syndrome (DS) and euploid fetuses, we used Affymetrix microarrays to compare gene expression in uncultured amniotic fluid supernatant samples.