Entry Detail



General Information

Database ID:exR0076139
RNA Name:LMNB2
RNA Type:mRNA
Chromosome:chr19
Starnd:-
Coordinate:
Start Site(bp):2427638End Site(bp):2456959
External Links:ENSG00000176619



Disease Information

Disease Name:Fragile X Syndrome
Disease Category:Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH ID:D005600
Type:Diseases Category/Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Alias:Fragile X Syndromes//Syndrome, Fragile X//Syndromes, Fragile X//Marker X Syndrome//Marker X Syndromes//Syndrome, Marker X//Syndromes, Marker X//Mental Retardation, X-Linked, Associated With Marxq28//X-Linked Mental Retardation and Macroorchidism//X Linked Mental Retardation and Macroorchidism//Fragile X Mental Retardation Syndrome//Martin-Bell Syndrome//Martin Bell Syndrome//Syndrome, Martin-Bell//Fra(X) Syndrome//FRAXE Syndrome//FRAXE Syndromes//Syndrome, FRAXE//Syndromes, FRAXE//Mental Retardation, X-Linked, Associated With Fragile Site Fraxe//Fragile X-F Mental Retardation Syndrome//Mar (X) Syndrome//FRAXA Syndrome//FRAXA Syndromes//Syndrome, FRAXA//Syndromes, FRAXA



Expression Detail

GEO ID:GSE83556
Description:Global transcriptome dysregulation in second trimester fetuses with FMR1 expansions
Experimental Design:Disease vs Control
Case Disease Type:Fragile X Syndrome
Case Disease SubType:NA
Case Sample:Fragile X Syndrome
Control Sample:Normal
Number of Case:22
Number of Control:18
Number of Samples:40





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
AASS
chr7
122073549
122144255
-
ABI3
chr17
49210411
49223225
+
AC005258.1
chr19
2269525
2341172
+
AC008878.3
chr19
7382834
7470241
+
AC011448.1
chr19
19516227
19536076
+
AC138696.1
chr8
143247110
143276403
+
AC138811.2
chr16
18788063
18801519
-
AC138969.1
chr16
16317444
16350590
+
ACTB
chr7
5527148
5563784
-
ACTG1
chr17
81509971
81523847
-
ACTN4
chr19
38647649
38731589
+
ADAM11
chr17
44758988
44781846
+
ADD1
chr4
2843857
2930076
+
ADK
chr10
74151202
74709963
+
ADM2
chr22
50481543
50486440
+
AGAP1
chr2
235494043
236131800
+
AHCY
chr20
34280268
34311802
-
AHCYL2
chr7
129225023
129430211
+
AHSA1
chr14
77457870
77469472
+
AKAP17A
chrX
1591604
1602520
+
AKT1
chr14
104769349
104795751
-
AL021546.1
chr12
120438198
120460006
+
ALAS1
chr3
52198086
52214327
+
ALDH9A1
chr1
165662216
165698863
-
miRNA targets:
miRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa-miR-4485-3p
chr11
10508277
10508296
-
circRNA targets:NA
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AL022157.1
chrX
57121662
57127243
+
AL096828.3
chr20
63218041
63218502
+
AL117335.1
chr20
1888128
1894374
-
AL118516.1
chr22
46761894
46762563
-
Display:



Experiment Detail

GEO ID:GSE83556
Sample Source:Amniotic Fluid
Source Fraction:Supernatant
Platform:GPL570
Method:Microarray
Num of detected RNA Type:1
Num of detected RNAs of this Type:17063
Sample treatment protocol:RNA was extracted from 5-15 mL amniotic fluid supernatant (centrifugation at 350g, 4C, 10, min).
RNA Extract protocol:All samples were processed using the Qiagen Circulating Nucleic Acid kit with an on-column DNase digestion step to remove genomic DNA. The RNA was then purified and concentrated with the RNeasy MinElute Clean up kit and eluted in RNasefree water.
RNA library preparation protocol:RNA was converted to cDNA and amplified using the Ovation Pico WTA kit V2 and then purified with the QIAquick PCR Purification kit. Samples were labeled using the Encore Biotin Module (NuGEN, San Carlos, CA)Samples were labeled using the Encore Biotin Module (NuGEN, San Carlos, CA).



Reference

PMID:NA
Title:NA
Author:NA
Journal:NA
Description:NA