exRNAdisease

General Information

Database ID:

exR0076678

RNA Name:

MDK

RNA Type:

mRNA

Chromosome:

chr11

Starnd:

Coordinate:

Start Site(bp):

46380756

End Site(bp):

46383837

External Links:

Disease Information

Disease Name:	Fragile X Syndrome
Disease Category:	Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH ID:	D005600
Type:	Diseases Category/Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Alias:	Fragile X Syndromes//Syndrome, Fragile X//Syndromes, Fragile X//Marker X Syndrome//Marker X Syndromes//Syndrome, Marker X//Syndromes, Marker X//Mental Retardation, X-Linked, Associated With Marxq28//X-Linked Mental Retardation and Macroorchidism//X Linked Mental Retardation and Macroorchidism//Fragile X Mental Retardation Syndrome//Martin-Bell Syndrome//Martin Bell Syndrome//Syndrome, Martin-Bell//Fra(X) Syndrome//FRAXE Syndrome//FRAXE Syndromes//Syndrome, FRAXE//Syndromes, FRAXE//Mental Retardation, X-Linked, Associated With Fragile Site Fraxe//Fragile X-F Mental Retardation Syndrome//Mar (X) Syndrome//FRAXA Syndrome//FRAXA Syndromes//Syndrome, FRAXA//Syndromes, FRAXA

Expression Detail

GEO ID:	GSE83556
Description:	Global transcriptome dysregulation in second trimester fetuses with FMR1 expansions
Experimental Design:	Disease vs Control
Case Disease Type:	Fragile X Syndrome
Case Disease SubType:	NA
Case Sample:	Fragile X Syndrome
Control Sample:	Normal
Number of Case:	22
Number of Control:	18
Number of Samples:	40

Regulatory Relationship

mRNA targets:

Gene Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
AC092143.1	chr16	89919165	89936092	+
AEN	chr15	88621337	88632281	+
AKIRIN1	chr1	38991276	39006059	+
AC013394.1	chr15	92883413	92949230	+
ALDOA	chr16	30064164	30070457	+
AK2	chr1	33007940	33080996	-
ADGRB1	chr8	142449430	142545009	+
AHSA1	chr14	77457870	77469472	+
ACTG1	chr17	81509971	81523847	-
ABHD14A-ACY1	chr3	51974706	51989183	+
AK4	chr1	65147549	65232145	+
AC093525.2	chr16	2496032	2520218	+
AL139011.2	chr1	160216800	160285130	-
ADAT3	chr19	1905399	1913447	+
AC008878.3	chr19	7382834	7470241	+
AHNAK	chr11	62433542	62556235	-
ADIPOR1	chr1	202940826	202958572	-
ABRACL	chr6	139028745	139043302	+
ABHD8	chr19	17292131	17310236	-
AL121845.3	chr20	63708864	63739103	+
AKR1A1	chr1	45550543	45570049	+
AC058822.1	chr4	53377839	54295272	+
ACY1	chr3	51983340	51989197	+
AC093668.1	chr7	102541501	102592444	-
ABL1	chr9	130713016	130887675	+
AC007192.1	chr19	18153158	18178117	+
AC011448.1	chr19	19516227	19536076	+
AC245033.1	chr15	82536788	82573194	-
ABCF1	chr6	30571393	30597179	+
AC104581.2	chr17	7925931	7930622	-

miRNA targets:

miRNA Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
hsa-miR-204-5p	chr9	70810031	70810052	-
hsa-miR-211-5p	chr15	31065095	31065116	-
hsa-miR-124-3p	chr8	64379210	64379231	+
hsa-miR-185-5p	chr22	20033153	20033174	+
hsa-miR-642a-5p	chr19	45674943	45674964	+
hsa-miR-624-3p	chr14	31014669	31014689	-
hsa-miR-3654	chr7	133034860	133034878	-

circRNA targets:

lncRNA targets:

lncRNA Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
AC007952.4	chr17	19112000	19112636	-
AC010615.2	chr19	21444241	21463908	-
AC011468.2	chr19	52130548	52171533	-
AC068134.2	chr2	232420661	232421461	-
AC132217.1	chr11	2129121	2129964	-
AD000090.1	chr19	35557956	35581954	+
AL022311.1	chr22	37876148	37895563	+

Display:

Experiment Detail

GEO ID:	GSE83556
Sample Source:	Amniotic Fluid
Source Fraction:	Supernatant
Platform:	GPL570
Method:	Microarray
Num of detected RNA Type:	1
Num of detected RNAs of this Type:	17063
Sample treatment protocol:	RNA was extracted from 5-15 mL amniotic fluid supernatant (centrifugation at 350g, 4C, 10, min).
RNA Extract protocol:	All samples were processed using the Qiagen Circulating Nucleic Acid kit with an on-column DNase digestion step to remove genomic DNA. The RNA was then purified and concentrated with the RNeasy MinElute Clean up kit and eluted in RNasefree water.
RNA library preparation protocol:	RNA was converted to cDNA and amplified using the Ovation Pico WTA kit V2 and then purified with the QIAquick PCR Purification kit. Samples were labeled using the Encore Biotin Module (NuGEN, San Carlos, CA)Samples were labeled using the Encore Biotin Module (NuGEN, San Carlos, CA).

Reference