exRNAdisease

General Information

Database ID:

exR0077895

RNA Name:

NPM1

RNA Type:

mRNA

Chromosome:

chr5

Starnd:

Coordinate:

Start Site(bp):

171387116

End Site(bp):

171411137

External Links:

Disease Information

Disease Name:	Fragile X Syndrome
Disease Category:	Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH ID:	D005600
Type:	Diseases Category/Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Alias:	Fragile X Syndromes//Syndrome, Fragile X//Syndromes, Fragile X//Marker X Syndrome//Marker X Syndromes//Syndrome, Marker X//Syndromes, Marker X//Mental Retardation, X-Linked, Associated With Marxq28//X-Linked Mental Retardation and Macroorchidism//X Linked Mental Retardation and Macroorchidism//Fragile X Mental Retardation Syndrome//Martin-Bell Syndrome//Martin Bell Syndrome//Syndrome, Martin-Bell//Fra(X) Syndrome//FRAXE Syndrome//FRAXE Syndromes//Syndrome, FRAXE//Syndromes, FRAXE//Mental Retardation, X-Linked, Associated With Fragile Site Fraxe//Fragile X-F Mental Retardation Syndrome//Mar (X) Syndrome//FRAXA Syndrome//FRAXA Syndromes//Syndrome, FRAXA//Syndromes, FRAXA

Expression Detail

GEO ID:	GSE83556
Description:	Global transcriptome dysregulation in second trimester fetuses with FMR1 expansions
Experimental Design:	Disease vs Control
Case Disease Type:	Fragile X Syndrome
Case Disease SubType:	NA
Case Sample:	Fragile X Syndrome
Control Sample:	Normal
Number of Case:	22
Number of Control:	18
Number of Samples:	40

Regulatory Relationship

mRNA targets:

Gene Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
AC073508.2	chr17	40627356	40665141	-
AL121594.1	chr14	35122549	35317474	+
AC092143.1	chr16	89919165	89936092	+
AC007192.1	chr19	18153158	18178117	+
ACTB	chr7	5527148	5563784	-
ADH5	chr4	99070978	99088801	-
AC138969.1	chr16	16317444	16350590	+
ABCC1	chr16	15949577	16143074	+
AC008982.1	chr19	38817471	38840178	-
AC004922.1	chr7	99325879	99394653	+
AL365205.1	chr6	41780349	41790141	+
ADD1	chr4	2843857	2930076	+
AC126283.2	chr4	109713916	109801999	-
AC005258.1	chr19	2269525	2341172	+
AL031708.1	chr16	1632259	1686715	+
AL139011.2	chr1	160216800	160285130	-
ADAM23	chr2	206443532	206621127	+
ABT1	chr6	26596953	26600739	+
ALDH2	chr12	111766887	111817532	+
AGPAT5	chr8	6708642	6761503	+
ADGRG6	chr6	142301854	142446266	+
AC120057.2	chr17	7240427	7244635	-
ACTG1	chr17	81509971	81523847	-
AHCYL1	chr1	109984765	110023742	+
AACS	chr12	125065434	125143333	+
ADGRD1	chr12	130953907	131141469	+
ALDH18A1	chr10	95605941	95656711	-
ALDH3A2	chr17	19648136	19685760	+
ACTR1A	chr10	102461881	102502712	-
AC010463.1	chr19	17267418	17282966	+

miRNA targets:

miRNA Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
hsa-miR-92a-3p	chrX	134169544	134169565	-

circRNA targets:

lncRNA targets:

lncRNA Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
AC007218.1	chr16	9666885	9676843	-
AC007952.4	chr17	19112000	19112636	-
AC011498.1	chr19	4457962	4471493	-
AC022140.1	chr5	25404733	25445925	-
AD000090.1	chr19	35557956	35581954	+
AL021707.1	chr22	38739003	38749041	+
AL137003.1	chr6	16764346	16766883	+

Display:

Experiment Detail

GEO ID:	GSE83556
Sample Source:	Amniotic Fluid
Source Fraction:	Supernatant
Platform:	GPL570
Method:	Microarray
Num of detected RNA Type:	1
Num of detected RNAs of this Type:	17063
Sample treatment protocol:	RNA was extracted from 5-15 mL amniotic fluid supernatant (centrifugation at 350g, 4C, 10, min).
RNA Extract protocol:	All samples were processed using the Qiagen Circulating Nucleic Acid kit with an on-column DNase digestion step to remove genomic DNA. The RNA was then purified and concentrated with the RNeasy MinElute Clean up kit and eluted in RNasefree water.
RNA library preparation protocol:	RNA was converted to cDNA and amplified using the Ovation Pico WTA kit V2 and then purified with the QIAquick PCR Purification kit. Samples were labeled using the Encore Biotin Module (NuGEN, San Carlos, CA)Samples were labeled using the Encore Biotin Module (NuGEN, San Carlos, CA).

Reference