exRNAdisease

General Information

Database ID:

exR0078398

RNA Name:

PABPC1

RNA Type:

mRNA

Chromosome:

chr8

Starnd:

Coordinate:

Start Site(bp):

100685816

End Site(bp):

100722809

External Links:

Disease Information

Disease Name:	Fragile X Syndrome
Disease Category:	Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH ID:	D005600
Type:	Diseases Category/Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Alias:	Fragile X Syndromes//Syndrome, Fragile X//Syndromes, Fragile X//Marker X Syndrome//Marker X Syndromes//Syndrome, Marker X//Syndromes, Marker X//Mental Retardation, X-Linked, Associated With Marxq28//X-Linked Mental Retardation and Macroorchidism//X Linked Mental Retardation and Macroorchidism//Fragile X Mental Retardation Syndrome//Martin-Bell Syndrome//Martin Bell Syndrome//Syndrome, Martin-Bell//Fra(X) Syndrome//FRAXE Syndrome//FRAXE Syndromes//Syndrome, FRAXE//Syndromes, FRAXE//Mental Retardation, X-Linked, Associated With Fragile Site Fraxe//Fragile X-F Mental Retardation Syndrome//Mar (X) Syndrome//FRAXA Syndrome//FRAXA Syndromes//Syndrome, FRAXA//Syndromes, FRAXA

Expression Detail

GEO ID:	GSE83556
Description:	Global transcriptome dysregulation in second trimester fetuses with FMR1 expansions
Experimental Design:	Disease vs Control
Case Disease Type:	Fragile X Syndrome
Case Disease SubType:	NA
Case Sample:	Fragile X Syndrome
Control Sample:	Normal
Number of Case:	22
Number of Control:	18
Number of Samples:	40

Regulatory Relationship

mRNA targets:

Gene Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
ALDH18A1	chr10	95605941	95656711	-
AC027796.3	chr17	3585149	3636249	-
ACOX3	chr4	8366282	8440723	-
ABHD14B	chr3	51968510	51983409	-
ADNP2	chr18	80109262	80147523	+
AGPAT5	chr8	6708642	6761503	+
AL022318.4	chr22	39014363	39033276	+
ADH5	chr4	99070978	99088801	-
ALDH1B1	chr9	38392702	38398661	+
ACTL6A	chr3	179562886	179588407	+
ADCY1	chr7	45574140	45723116	+
ADAR	chr1	154582057	154628013	-
AFDN	chr6	167826922	167972023	+
ABT1	chr6	26596953	26600739	+
AC010422.3	chr19	12643831	12648397	-
ACTG1	chr17	81509971	81523847	-
AKAP9	chr7	91940867	92110673	+
AC116366.3	chr5	132410832	132646079	+
AC138811.2	chr16	18788063	18801519	-
ACTB	chr7	5527148	5563784	-
AC011005.1	chr7	129126518	129130793	+
ALDH9A1	chr1	165662216	165698863	-
AHDC1	chr1	27534035	27604431	-
AC010463.1	chr19	17267418	17282966	+
ADAMTS7	chr15	78759206	78811464	-
AFG1L	chr6	108294991	108526796	+
ADAMTSL4	chr1	150549369	150560937	+
AC008982.1	chr19	38817471	38840178	-
AC020909.1	chr19	50415799	50428409	+
AC118549.1	chr1	77562416	77683419	-

miRNA targets:

miRNA Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
hsa-miR-4709-5p	chr14	74480175	74480196	-
hsa-miR-3620-5p	chr1	228097285	228097306	+
hsa-miR-7705	chr8	100703002	100703024	-

circRNA targets:

lncRNA targets:

lncRNA Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
AC007952.4	chr17	19112000	19112636	-
AC010442.1	chr5	466124	473098	-
AC016876.2	chr17	7581964	7584086	-
AC068473.5	chr18	79677287	79679358	-
AC114271.1	chr19	10333436	10336248	+
AD000090.1	chr19	35557956	35581954	+
AL121985.1	chr1	160670778	160699761	+

Display:

Experiment Detail

GEO ID:	GSE83556
Sample Source:	Amniotic Fluid
Source Fraction:	Supernatant
Platform:	GPL570
Method:	Microarray
Num of detected RNA Type:	1
Num of detected RNAs of this Type:	17063
Sample treatment protocol:	RNA was extracted from 5-15 mL amniotic fluid supernatant (centrifugation at 350g, 4C, 10, min).
RNA Extract protocol:	All samples were processed using the Qiagen Circulating Nucleic Acid kit with an on-column DNase digestion step to remove genomic DNA. The RNA was then purified and concentrated with the RNeasy MinElute Clean up kit and eluted in RNasefree water.
RNA library preparation protocol:	RNA was converted to cDNA and amplified using the Ovation Pico WTA kit V2 and then purified with the QIAquick PCR Purification kit. Samples were labeled using the Encore Biotin Module (NuGEN, San Carlos, CA)Samples were labeled using the Encore Biotin Module (NuGEN, San Carlos, CA).

Reference