exRNAdisease

General Information

Database ID:

exR0079793

RNA Name:

PTMS

RNA Type:

mRNA

Chromosome:

chr12

Starnd:

Coordinate:

Start Site(bp):

6765516

End Site(bp):

6770952

External Links:

Disease Information

Disease Name:	Fragile X Syndrome
Disease Category:	Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH ID:	D005600
Type:	Diseases Category/Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Alias:	Fragile X Syndromes//Syndrome, Fragile X//Syndromes, Fragile X//Marker X Syndrome//Marker X Syndromes//Syndrome, Marker X//Syndromes, Marker X//Mental Retardation, X-Linked, Associated With Marxq28//X-Linked Mental Retardation and Macroorchidism//X Linked Mental Retardation and Macroorchidism//Fragile X Mental Retardation Syndrome//Martin-Bell Syndrome//Martin Bell Syndrome//Syndrome, Martin-Bell//Fra(X) Syndrome//FRAXE Syndrome//FRAXE Syndromes//Syndrome, FRAXE//Syndromes, FRAXE//Mental Retardation, X-Linked, Associated With Fragile Site Fraxe//Fragile X-F Mental Retardation Syndrome//Mar (X) Syndrome//FRAXA Syndrome//FRAXA Syndromes//Syndrome, FRAXA//Syndromes, FRAXA

Expression Detail

GEO ID:	GSE83556
Description:	Global transcriptome dysregulation in second trimester fetuses with FMR1 expansions
Experimental Design:	Disease vs Control
Case Disease Type:	Fragile X Syndrome
Case Disease SubType:	NA
Case Sample:	Fragile X Syndrome
Control Sample:	Normal
Number of Case:	22
Number of Control:	18
Number of Samples:	40

Regulatory Relationship

mRNA targets:

Gene Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
AARSD1	chr17	42950526	42964498	-
ABCG2	chr4	88090150	88231628	-
ABHD16A	chr6	31686955	31703356	-
ABHD8	chr19	17292131	17310236	-
ABI1	chr10	26746593	26861087	-
AC010422.3	chr19	12643831	12648397	-
AC011462.1	chr19	41350853	41425001	+
AC073508.2	chr17	40627356	40665141	-
AC073896.1	chr12	56285916	56316059	-
AC087289.3	chr17	75898645	75930129	-
AC131160.1	chr3	183815568	183884889	-
AC245033.1	chr15	82536788	82573194	-
ACIN1	chr14	23058564	23095614	-
ACO2	chr22	41469117	41528989	+
ACTB	chr7	5527148	5563784	-
ACTG1	chr17	81509971	81523847	-
ACTN1	chr14	68874143	68979440	-
ACTR3	chr2	113890063	113962596	+
AHCY	chr20	34280268	34311802	-
AKAP13	chr15	85380571	85749358	+
AL136454.1	chr1	192716132	192716653	+
AL162417.1	chr9	133098121	133163914	-
ALDH16A1	chr19	49453225	49471050	+

miRNA targets:

miRNA Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
hsa-miR-185-5p	chr22	20033153	20033174	+
hsa-miR-423-5p	chr17	30117095	30117117	+
hsa-miR-708-5p	chr11	79402077	79402099	-
hsa-miR-1294	chr5	154347153	154347174	+
hsa-miR-1270	chr19	20399320	20399342	-
hsa-miR-1276	chr15	85770548	85770567	-
hsa-miR-3917	chr1	25906384	25906403	-

circRNA targets:

lncRNA targets:

lncRNA Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
AC006064.5	chr12	6510275	6510522	+
AC006460.2	chr2	190607660	190649840	-
AC125807.2	chr12	3041437	3044950	+
AC245033.4	chr15	82533175	82540008	-
AL117378.1	chr6	131901963	131920565	+

Display:

Experiment Detail

GEO ID:	GSE83556
Sample Source:	Amniotic Fluid
Source Fraction:	Supernatant
Platform:	GPL570
Method:	Microarray
Num of detected RNA Type:	1
Num of detected RNAs of this Type:	17063
Sample treatment protocol:	RNA was extracted from 5-15 mL amniotic fluid supernatant (centrifugation at 350g, 4C, 10, min).
RNA Extract protocol:	All samples were processed using the Qiagen Circulating Nucleic Acid kit with an on-column DNase digestion step to remove genomic DNA. The RNA was then purified and concentrated with the RNeasy MinElute Clean up kit and eluted in RNasefree water.
RNA library preparation protocol:	RNA was converted to cDNA and amplified using the Ovation Pico WTA kit V2 and then purified with the QIAquick PCR Purification kit. Samples were labeled using the Encore Biotin Module (NuGEN, San Carlos, CA)Samples were labeled using the Encore Biotin Module (NuGEN, San Carlos, CA).

Reference