exRNAdisease

General Information

Database ID:

exR0080622

RNA Name:

RPLP2

RNA Type:

mRNA

Chromosome:

chr11

Starnd:

Coordinate:

Start Site(bp):

809965

End Site(bp):

812880

External Links:

Disease Information

Disease Name:	Fragile X Syndrome
Disease Category:	Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH ID:	D005600
Type:	Diseases Category/Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Alias:	Fragile X Syndromes//Syndrome, Fragile X//Syndromes, Fragile X//Marker X Syndrome//Marker X Syndromes//Syndrome, Marker X//Syndromes, Marker X//Mental Retardation, X-Linked, Associated With Marxq28//X-Linked Mental Retardation and Macroorchidism//X Linked Mental Retardation and Macroorchidism//Fragile X Mental Retardation Syndrome//Martin-Bell Syndrome//Martin Bell Syndrome//Syndrome, Martin-Bell//Fra(X) Syndrome//FRAXE Syndrome//FRAXE Syndromes//Syndrome, FRAXE//Syndromes, FRAXE//Mental Retardation, X-Linked, Associated With Fragile Site Fraxe//Fragile X-F Mental Retardation Syndrome//Mar (X) Syndrome//FRAXA Syndrome//FRAXA Syndromes//Syndrome, FRAXA//Syndromes, FRAXA

Expression Detail

GEO ID:	GSE83556
Description:	Global transcriptome dysregulation in second trimester fetuses with FMR1 expansions
Experimental Design:	Disease vs Control
Case Disease Type:	Fragile X Syndrome
Case Disease SubType:	NA
Case Sample:	Fragile X Syndrome
Control Sample:	Normal
Number of Case:	22
Number of Control:	18
Number of Samples:	40

Regulatory Relationship

mRNA targets:

Gene Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
AC010646.1	chr19	17235940	17255448	-
ALDOA	chr16	30064164	30070457	+
AL139300.1	chr14	103562962	103685924	+
AC011455.2	chr19	38915404	38949855	-
AGO4	chr1	35808016	35857890	+
AKAP1	chr17	57085092	57121346	+
AC007192.1	chr19	18153158	18178117	+
AC135050.2	chr16	31083439	31094956	-
ADGRL2	chr1	81306160	81992436	+
AC010422.3	chr19	12643831	12648397	-
AC020915.5	chr19	58228914	58315183	+
AKT2	chr19	40230317	40285536	-
AFTPH	chr2	64524305	64593005	+
ACIN1	chr14	23058564	23095614	-
AIFM1	chrX	130129362	130165887	-
AC004922.1	chr7	99325879	99394653	+
AL049629.2	chr11	33698261	33722467	-
ADCY1	chr7	45574140	45723116	+
ACTG1	chr17	81509971	81523847	-
AFDN	chr6	167826922	167972023	+
AC005258.1	chr19	2269525	2341172	+
ADRM1	chr20	62302093	62308862	+
AL121594.1	chr14	35122549	35317474	+
ALDH18A1	chr10	95605941	95656711	-
AGRN	chr1	1020120	1056118	+
ADH5	chr4	99070978	99088801	-
AACS	chr12	125065434	125143333	+
AGBL5	chr2	27042364	27070622	+
ABCF1	chr6	30571393	30597179	+
AC008878.3	chr19	7382834	7470241	+

miRNA targets:

miRNA Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
hsa-miR-7705	chr8	100703002	100703024	-

circRNA targets:

lncRNA targets:

lncRNA Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
AC007780.1	chr17	68413623	68524949	+
AC017104.1	chr2	231388976	231394991	+
AC018521.1	chr17	47945424	47981736	+
AC026362.1	chr12	122975320	122982907	+
AD000090.1	chr19	35557956	35581954	+
AL137782.1	chr13	75549773	75807120	+

Display:

Experiment Detail

GEO ID:	GSE83556
Sample Source:	Amniotic Fluid
Source Fraction:	Supernatant
Platform:	GPL570
Method:	Microarray
Num of detected RNA Type:	1
Num of detected RNAs of this Type:	17063
Sample treatment protocol:	RNA was extracted from 5-15 mL amniotic fluid supernatant (centrifugation at 350g, 4C, 10, min).
RNA Extract protocol:	All samples were processed using the Qiagen Circulating Nucleic Acid kit with an on-column DNase digestion step to remove genomic DNA. The RNA was then purified and concentrated with the RNeasy MinElute Clean up kit and eluted in RNasefree water.
RNA library preparation protocol:	RNA was converted to cDNA and amplified using the Ovation Pico WTA kit V2 and then purified with the QIAquick PCR Purification kit. Samples were labeled using the Encore Biotin Module (NuGEN, San Carlos, CA)Samples were labeled using the Encore Biotin Module (NuGEN, San Carlos, CA).

Reference