exRNAdisease

General Information

Database ID:

exR0082159

RNA Name:

SREBF2

RNA Type:

mRNA

Chromosome:

chr22

Starnd:

Coordinate:

Start Site(bp):

41833079

End Site(bp):

41907307

External Links:

Disease Information

Disease Name:	Fragile X Syndrome
Disease Category:	Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH ID:	D005600
Type:	Diseases Category/Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Alias:	Fragile X Syndromes//Syndrome, Fragile X//Syndromes, Fragile X//Marker X Syndrome//Marker X Syndromes//Syndrome, Marker X//Syndromes, Marker X//Mental Retardation, X-Linked, Associated With Marxq28//X-Linked Mental Retardation and Macroorchidism//X Linked Mental Retardation and Macroorchidism//Fragile X Mental Retardation Syndrome//Martin-Bell Syndrome//Martin Bell Syndrome//Syndrome, Martin-Bell//Fra(X) Syndrome//FRAXE Syndrome//FRAXE Syndromes//Syndrome, FRAXE//Syndromes, FRAXE//Mental Retardation, X-Linked, Associated With Fragile Site Fraxe//Fragile X-F Mental Retardation Syndrome//Mar (X) Syndrome//FRAXA Syndrome//FRAXA Syndromes//Syndrome, FRAXA//Syndromes, FRAXA

Expression Detail

GEO ID:	GSE83556
Description:	Global transcriptome dysregulation in second trimester fetuses with FMR1 expansions
Experimental Design:	Disease vs Control
Case Disease Type:	Fragile X Syndrome
Case Disease SubType:	NA
Case Sample:	Fragile X Syndrome
Control Sample:	Normal
Number of Case:	22
Number of Control:	18
Number of Samples:	40

Regulatory Relationship

mRNA targets:

Gene Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
AATF	chr17	36948954	37056871	+
ABCG2	chr4	88090150	88231628	-
AC005258.1	chr19	2269525	2341172	+
AC010422.3	chr19	12643831	12648397	-
AC015813.2	chr17	57989038	58007246	-
AC087289.3	chr17	75898645	75930129	-
AC118549.1	chr1	77562416	77683419	-
AC245033.1	chr15	82536788	82573194	-
ACLY	chr17	41866917	41930542	-
ACO2	chr22	41469117	41528989	+
ACSS3	chr12	80936414	81261210	+
ACTB	chr7	5527148	5563784	-
ACTN1	chr14	68874143	68979440	-
ADD2	chr2	70607618	70768225	-
ADGRG6	chr6	142301854	142446266	+
ADRM1	chr20	62302093	62308862	+
AFDN	chr6	167826922	167972023	+
AGO2	chr8	140520156	140635633	-
AKIRIN1	chr1	38991276	39006059	+
AKIRIN2	chr6	87674860	87702233	-
AL645941.2	chr6	32937364	32953122	-
ALDOA	chr16	30064164	30070457	+

miRNA targets:

miRNA Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
hsa-miR-185-5p	chr22	20033153	20033174	+
hsa-miR-625-5p	chr14	65471116	65471136	+
hsa-miR-650	chr22	22822791	22822811	+
hsa-miR-423-5p	chr17	30117095	30117117	+
hsa-miR-33a-3p	chr22	41900989	41901010	+

circRNA targets:

lncRNA targets:

lncRNA Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
AC007952.4	chr17	19112000	19112636	-
AC026362.1	chr12	122975320	122982907	+
AC064807.1	chr8	51899268	51949874	+
AC078846.1	chr7	129604548	129611630	-
AC106864.1	chr4	112693047	112706810	-
AC132217.1	chr11	2129121	2129964	-
AC135048.1	chr16	30948386	30956511	+
AC138035.2	chr5	181329241	181342213	+
AC245033.4	chr15	82533175	82540008	-

Display:

Experiment Detail

GEO ID:	GSE83556
Sample Source:	Amniotic Fluid
Source Fraction:	Supernatant
Platform:	GPL570
Method:	Microarray
Num of detected RNA Type:	1
Num of detected RNAs of this Type:	17063
Sample treatment protocol:	RNA was extracted from 5-15 mL amniotic fluid supernatant (centrifugation at 350g, 4C, 10, min).
RNA Extract protocol:	All samples were processed using the Qiagen Circulating Nucleic Acid kit with an on-column DNase digestion step to remove genomic DNA. The RNA was then purified and concentrated with the RNeasy MinElute Clean up kit and eluted in RNasefree water.
RNA library preparation protocol:	RNA was converted to cDNA and amplified using the Ovation Pico WTA kit V2 and then purified with the QIAquick PCR Purification kit. Samples were labeled using the Encore Biotin Module (NuGEN, San Carlos, CA)Samples were labeled using the Encore Biotin Module (NuGEN, San Carlos, CA).

Reference