exRNAdisease

General Information

Database ID:

exR0083823

RNA Name:

TUBA1B

RNA Type:

mRNA

Chromosome:

chr12

Starnd:

Coordinate:

Start Site(bp):

49127782

End Site(bp):

49131397

External Links:

Disease Information

Disease Name:	Fragile X Syndrome
Disease Category:	Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH ID:	D005600
Type:	Diseases Category/Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Alias:	Fragile X Syndromes//Syndrome, Fragile X//Syndromes, Fragile X//Marker X Syndrome//Marker X Syndromes//Syndrome, Marker X//Syndromes, Marker X//Mental Retardation, X-Linked, Associated With Marxq28//X-Linked Mental Retardation and Macroorchidism//X Linked Mental Retardation and Macroorchidism//Fragile X Mental Retardation Syndrome//Martin-Bell Syndrome//Martin Bell Syndrome//Syndrome, Martin-Bell//Fra(X) Syndrome//FRAXE Syndrome//FRAXE Syndromes//Syndrome, FRAXE//Syndromes, FRAXE//Mental Retardation, X-Linked, Associated With Fragile Site Fraxe//Fragile X-F Mental Retardation Syndrome//Mar (X) Syndrome//FRAXA Syndrome//FRAXA Syndromes//Syndrome, FRAXA//Syndromes, FRAXA

Expression Detail

GEO ID:	GSE83556
Description:	Global transcriptome dysregulation in second trimester fetuses with FMR1 expansions
Experimental Design:	Disease vs Control
Case Disease Type:	Fragile X Syndrome
Case Disease SubType:	NA
Case Sample:	Fragile X Syndrome
Control Sample:	Normal
Number of Case:	22
Number of Control:	18
Number of Samples:	40

Regulatory Relationship

mRNA targets:

Gene Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
ADIPOR1	chr1	202940826	202958572	-
AKIRIN1	chr1	38991276	39006059	+
AEN	chr15	88621337	88632281	+
ADCY5	chr3	123282296	123449758	-
ALDOA	chr16	30064164	30070457	+
AK2	chr1	33007940	33080996	-
ADRM1	chr20	62302093	62308862	+
ABRACL	chr6	139028745	139043302	+
ACSS2	chr20	34872146	34927962	+
AGFG2	chr7	100539203	100568220	+
ACTN4	chr19	38647649	38731589	+
AGBL5	chr2	27042364	27070622	+
ABI2	chr2	203328239	203447728	+
AC008878.3	chr19	7382834	7470241	+
ADGRG6	chr6	142301854	142446266	+
ACVR2B	chr3	38453890	38493142	+
AC120057.2	chr17	7240427	7244635	-
AC138811.2	chr16	18788063	18801519	-
ABHD14A-ACY1	chr3	51974706	51989183	+
ADD1	chr4	2843857	2930076	+
AC004922.1	chr7	99325879	99394653	+
ADSL	chr22	40346500	40390463	+
ACTG1	chr17	81509971	81523847	-
ADA	chr20	44619522	44652233	-
AC007192.1	chr19	18153158	18178117	+
AC007040.2	chr2	70939318	70995336	-
AC015813.2	chr17	57989038	58007246	-
ADAR	chr1	154582057	154628013	-
AC011448.1	chr19	19516227	19536076	+
AL136454.1	chr1	192716132	192716653	+

miRNA targets:

miRNA Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
hsa-miR-103a-3p	chr5	168560904	168560926	-
hsa-miR-106a-5p	chrX	134170244	134170266	-
hsa-miR-221-3p	chrX	45746180	45746202	-
hsa-miR-302c-3p	chr4	112648366	112648388	-
hsa-miR-652-3p	chrX	110055389	110055409	+
hsa-miR-1291	chr12	48654494	48654517	-
hsa-miR-3654	chr7	133034860	133034878	-
hsa-miR-4707-5p	chr14	22956998	22957020	-

circRNA targets:

lncRNA targets:

lncRNA Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
AC005618.1	chr5	141326210	141329357	+
AC007952.4	chr17	19112000	19112636	-
AC012485.1	chr2	238231684	238255633	+
AC016876.2	chr17	7581964	7584086	-
AC022167.2	chr16	8848105	8860456	+
AC023509.1	chr12	53441741	53467528	+
AC026362.1	chr12	122975320	122982907	+
AC069281.2	chr7	100572232	100578700	-
AC087190.3	chr16	9104848	9113181	+
AC104461.1	chr1	200333193	200478669	+
AC124067.3	chr8	37559992	37567477	+
AC245014.3	chr1	145281116	145281462	+
AD000090.1	chr19	35557956	35581954	+
AL049543.1	chr6	28587378	28591747	+
AL118516.1	chr22	46761894	46762563	-

Display:

Experiment Detail

GEO ID:	GSE83556
Sample Source:	Amniotic Fluid
Source Fraction:	Supernatant
Platform:	GPL570
Method:	Microarray
Num of detected RNA Type:	1
Num of detected RNAs of this Type:	17063
Sample treatment protocol:	RNA was extracted from 5-15 mL amniotic fluid supernatant (centrifugation at 350g, 4C, 10, min).
RNA Extract protocol:	All samples were processed using the Qiagen Circulating Nucleic Acid kit with an on-column DNase digestion step to remove genomic DNA. The RNA was then purified and concentrated with the RNeasy MinElute Clean up kit and eluted in RNasefree water.
RNA library preparation protocol:	RNA was converted to cDNA and amplified using the Ovation Pico WTA kit V2 and then purified with the QIAquick PCR Purification kit. Samples were labeled using the Encore Biotin Module (NuGEN, San Carlos, CA)Samples were labeled using the Encore Biotin Module (NuGEN, San Carlos, CA).

Reference