exRNAdisease

General Information

Database ID:

exR0083824

RNA Name:

TUBA1C

RNA Type:

mRNA

Chromosome:

chr12

Starnd:

Coordinate:

Start Site(bp):

49188736

End Site(bp):

49274603

External Links:

Disease Information

Disease Name:	Fragile X Syndrome
Disease Category:	Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH ID:	D005600
Type:	Diseases Category/Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Alias:	Fragile X Syndromes//Syndrome, Fragile X//Syndromes, Fragile X//Marker X Syndrome//Marker X Syndromes//Syndrome, Marker X//Syndromes, Marker X//Mental Retardation, X-Linked, Associated With Marxq28//X-Linked Mental Retardation and Macroorchidism//X Linked Mental Retardation and Macroorchidism//Fragile X Mental Retardation Syndrome//Martin-Bell Syndrome//Martin Bell Syndrome//Syndrome, Martin-Bell//Fra(X) Syndrome//FRAXE Syndrome//FRAXE Syndromes//Syndrome, FRAXE//Syndromes, FRAXE//Mental Retardation, X-Linked, Associated With Fragile Site Fraxe//Fragile X-F Mental Retardation Syndrome//Mar (X) Syndrome//FRAXA Syndrome//FRAXA Syndromes//Syndrome, FRAXA//Syndromes, FRAXA

Expression Detail

GEO ID:	GSE83556
Description:	Global transcriptome dysregulation in second trimester fetuses with FMR1 expansions
Experimental Design:	Disease vs Control
Case Disease Type:	Fragile X Syndrome
Case Disease SubType:	NA
Case Sample:	Fragile X Syndrome
Control Sample:	Normal
Number of Case:	22
Number of Control:	18
Number of Samples:	40

Regulatory Relationship

mRNA targets:

Gene Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
ADCK2	chr7	140672945	140696261	+
AHCYL1	chr1	109984765	110023742	+
ALDH7A1	chr5	126531200	126595362	-
AC010323.1	chr19	8308283	8321379	-
AL139011.2	chr1	160216800	160285130	-
ADNP2	chr18	80109262	80147523	+
ABR	chr17	1003518	1229738	-
ABCA2	chr9	137007234	137028922	-
ACBD5	chr10	27195214	27242130	-
AC027644.4	chr7	66628958	66811189	+
AC093525.2	chr16	2496032	2520218	+
ACAT2	chr6	159762045	159779112	+
AK9	chr6	109492856	109691217	-
ADORA1	chr1	203090654	203167405	+
AHCY	chr20	34280268	34311802	-
ACTB	chr7	5527148	5563784	-
AGTRAP	chr1	11736084	11754802	+
ACIN1	chr14	23058564	23095614	-
ACTR3	chr2	113890063	113962596	+
AGBL3	chr7	134986508	135147963	+
ACTG1	chr17	81509971	81523847	-
AGK	chr7	141551278	141655244	+
ACTL6A	chr3	179562886	179588407	+
AC008982.1	chr19	38817471	38840178	-
AL162231.3	chr9	34646645	34657113	+
ALDOA	chr16	30064164	30070457	+
AL136454.1	chr1	192716132	192716653	+
AC004922.1	chr7	99325879	99394653	+
AC092143.1	chr16	89919165	89936092	+
ACTR1B	chr2	97655939	97664044	-

miRNA targets:

miRNA Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
hsa-miR-367-3p	chr4	112647877	112647898	-
hsa-miR-3610	chr8	116874740	116874759	-
hsa-miR-3654	chr7	133034860	133034878	-

circRNA targets:

lncRNA targets:

lncRNA Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
AC004687.1	chr17	58330884	58332508	-
AC011298.1	chr2	240686334	240690414	+
AC026362.1	chr12	122975320	122982907	+
AC233266.2	chr2	91580336	91580863	+

Display:

Experiment Detail

GEO ID:	GSE83556
Sample Source:	Amniotic Fluid
Source Fraction:	Supernatant
Platform:	GPL570
Method:	Microarray
Num of detected RNA Type:	1
Num of detected RNAs of this Type:	17063
Sample treatment protocol:	RNA was extracted from 5-15 mL amniotic fluid supernatant (centrifugation at 350g, 4C, 10, min).
RNA Extract protocol:	All samples were processed using the Qiagen Circulating Nucleic Acid kit with an on-column DNase digestion step to remove genomic DNA. The RNA was then purified and concentrated with the RNeasy MinElute Clean up kit and eluted in RNasefree water.
RNA library preparation protocol:	RNA was converted to cDNA and amplified using the Ovation Pico WTA kit V2 and then purified with the QIAquick PCR Purification kit. Samples were labeled using the Encore Biotin Module (NuGEN, San Carlos, CA)Samples were labeled using the Encore Biotin Module (NuGEN, San Carlos, CA).

Reference