Entry Detail



General Information

Database ID:exR0083837
RNA Name:TUBB4B
RNA Type:mRNA
Chromosome:chr9
Starnd:+
Coordinate:
Start Site(bp):137241287End Site(bp):137243707
External Links:ENSG00000188229



Disease Information

Disease Name:Fragile X Syndrome
Disease Category:Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH ID:D005600
Type:Diseases Category/Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Alias:Fragile X Syndromes//Syndrome, Fragile X//Syndromes, Fragile X//Marker X Syndrome//Marker X Syndromes//Syndrome, Marker X//Syndromes, Marker X//Mental Retardation, X-Linked, Associated With Marxq28//X-Linked Mental Retardation and Macroorchidism//X Linked Mental Retardation and Macroorchidism//Fragile X Mental Retardation Syndrome//Martin-Bell Syndrome//Martin Bell Syndrome//Syndrome, Martin-Bell//Fra(X) Syndrome//FRAXE Syndrome//FRAXE Syndromes//Syndrome, FRAXE//Syndromes, FRAXE//Mental Retardation, X-Linked, Associated With Fragile Site Fraxe//Fragile X-F Mental Retardation Syndrome//Mar (X) Syndrome//FRAXA Syndrome//FRAXA Syndromes//Syndrome, FRAXA//Syndromes, FRAXA



Expression Detail

GEO ID:GSE83556
Description:Global transcriptome dysregulation in second trimester fetuses with FMR1 expansions
Experimental Design:Disease vs Control
Case Disease Type:Fragile X Syndrome
Case Disease SubType:NA
Case Sample:Fragile X Syndrome
Control Sample:Normal
Number of Case:22
Number of Control:18
Number of Samples:40





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
ABHD5
chr3
43690108
43734371
+
ABLIM1
chr10
114431113
114768061
-
AC004922.1
chr7
99325879
99394653
+
AC008764.1
chr19
16479067
16628204
-
AC011511.4
chr19
10315471
10320678
-
AC068533.4
chr7
66087761
66152277
+
AC092143.1
chr16
89919165
89936092
+
ACBD6
chr1
180269653
180502954
-
ACLY
chr17
41866917
41930542
-
ACSS2
chr20
34872146
34927962
+
ACTR2
chr2
65227753
65271253
+
ADAM10
chr15
58588809
58749791
-
AEBP2
chr12
19404045
19720801
+
AEN
chr15
88621337
88632281
+
AGO4
chr1
35808016
35857890
+
AGRN
chr1
1020120
1056118
+
AIMP2
chr7
6009255
6023834
+
AKAP7
chr6
131135467
131283535
+
miRNA targets:NA
circRNA targets:NA
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC008105.3
chr17
45190931
45222222
-
AC008738.5
chr19
33301279
33301940
+
AC016355.1
chr15
67541072
67542604
-
AC022075.1
chr12
10363638
10398506
+
AD000090.1
chr19
35557956
35581954
+
Display:



Experiment Detail

GEO ID:GSE83556
Sample Source:Amniotic Fluid
Source Fraction:Supernatant
Platform:GPL570
Method:Microarray
Num of detected RNA Type:1
Num of detected RNAs of this Type:17063
Sample treatment protocol:RNA was extracted from 5-15 mL amniotic fluid supernatant (centrifugation at 350g, 4C, 10, min).
RNA Extract protocol:All samples were processed using the Qiagen Circulating Nucleic Acid kit with an on-column DNase digestion step to remove genomic DNA. The RNA was then purified and concentrated with the RNeasy MinElute Clean up kit and eluted in RNasefree water.
RNA library preparation protocol:RNA was converted to cDNA and amplified using the Ovation Pico WTA kit V2 and then purified with the QIAquick PCR Purification kit. Samples were labeled using the Encore Biotin Module (NuGEN, San Carlos, CA)Samples were labeled using the Encore Biotin Module (NuGEN, San Carlos, CA).



Reference

PMID:NA
Title:NA
Author:NA
Journal:NA
Description:NA