exRNAdisease

General Information

Database ID:

exR0083927

RNA Name:

UBC

RNA Type:

mRNA

Chromosome:

chr12

Starnd:

Coordinate:

Start Site(bp):

124911604

End Site(bp):

124917368

External Links:

Disease Information

Disease Name:	Fragile X Syndrome
Disease Category:	Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH ID:	D005600
Type:	Diseases Category/Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Alias:	Fragile X Syndromes//Syndrome, Fragile X//Syndromes, Fragile X//Marker X Syndrome//Marker X Syndromes//Syndrome, Marker X//Syndromes, Marker X//Mental Retardation, X-Linked, Associated With Marxq28//X-Linked Mental Retardation and Macroorchidism//X Linked Mental Retardation and Macroorchidism//Fragile X Mental Retardation Syndrome//Martin-Bell Syndrome//Martin Bell Syndrome//Syndrome, Martin-Bell//Fra(X) Syndrome//FRAXE Syndrome//FRAXE Syndromes//Syndrome, FRAXE//Syndromes, FRAXE//Mental Retardation, X-Linked, Associated With Fragile Site Fraxe//Fragile X-F Mental Retardation Syndrome//Mar (X) Syndrome//FRAXA Syndrome//FRAXA Syndromes//Syndrome, FRAXA//Syndromes, FRAXA

Expression Detail

GEO ID:	GSE83556
Description:	Global transcriptome dysregulation in second trimester fetuses with FMR1 expansions
Experimental Design:	Disease vs Control
Case Disease Type:	Fragile X Syndrome
Case Disease SubType:	NA
Case Sample:	Fragile X Syndrome
Control Sample:	Normal
Number of Case:	22
Number of Control:	18
Number of Samples:	40

Regulatory Relationship

mRNA targets:

Gene Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
ABCF2	chr7	151207837	151227166	-
AC008982.1	chr19	38817471	38840178	-
AC018523.2	chr11	14493783	14520344	-
AC026954.2	chr17	7312661	7319174	-
AC118553.2	chr1	99970011	100083321	+
AC124312.1	chr15	24955034	25000276	+
AC138811.2	chr16	18788063	18801519	-
ACADVL	chr17	7217125	7225266	+
ACOT2	chr14	73567620	73575658	+
ACP5	chr19	11574660	11579008	-
ACTB	chr7	5527148	5563784	-
ACTG1	chr17	81509971	81523847	-
ACY1	chr3	51983340	51989197	+
ADAM10	chr15	58588809	58749791	-
ADIPOR2	chr12	1688574	1788674	+
AEN	chr15	88621337	88632281	+
AFF1	chr4	86935002	87141054	+
AFP	chr4	73431138	73456174	+
AGPAT1	chr6	32168212	32178096	-
AKIRIN2	chr6	87674860	87702233	-
AL133352.1	chr10	100505628	100529881	-
AL136295.1	chr14	24189157	24213473	-
AL136295.4	chr14	24180395	24190416	-
AL136454.1	chr1	192716132	192716653	+
ALDOA	chr16	30064164	30070457	+

miRNA targets:

miRNA Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
hsa-miR-492	chr12	94834427	94834449	+
hsa-miR-1244	chr2	231713368	231713393	+
hsa-miR-4426	chr1	192716333	192716349	+

circRNA targets:

lncRNA targets:

lncRNA Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
AC048341.1	chr12	62602752	62622213	+
AC069281.2	chr7	100572232	100578700	-
AC091564.7	chr11	6610883	6616594	-
AC139149.1	chr17	81514047	81527776	+
AL022311.1	chr22	37876148	37895563	+
AL117378.1	chr6	131901963	131920565	+

Display:

Experiment Detail

GEO ID:	GSE83556
Sample Source:	Amniotic Fluid
Source Fraction:	Supernatant
Platform:	GPL570
Method:	Microarray
Num of detected RNA Type:	1
Num of detected RNAs of this Type:	17063
Sample treatment protocol:	RNA was extracted from 5-15 mL amniotic fluid supernatant (centrifugation at 350g, 4C, 10, min).
RNA Extract protocol:	All samples were processed using the Qiagen Circulating Nucleic Acid kit with an on-column DNase digestion step to remove genomic DNA. The RNA was then purified and concentrated with the RNeasy MinElute Clean up kit and eluted in RNasefree water.
RNA library preparation protocol:	RNA was converted to cDNA and amplified using the Ovation Pico WTA kit V2 and then purified with the QIAquick PCR Purification kit. Samples were labeled using the Encore Biotin Module (NuGEN, San Carlos, CA)Samples were labeled using the Encore Biotin Module (NuGEN, San Carlos, CA).

Reference