exRNAdisease

Entry Detail

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General Information

Database ID: exR0083990 RNA Name: UBR4 RNA Type: mRNA Chromosome: chr1 Starnd: - Coordinate: Start Site(bp): 19074510 End Site(bp): 19210266 External Links: ENSG00000127481

Disease Information

Disease Name: Fragile X Syndrome Disease Category: Congenital, Hereditary, and Neonatal Diseases and Abnormalities MeSH ID: D005600 Type: Diseases Category/Congenital, Hereditary, and Neonatal Diseases and Abnormalities Alias: Fragile X Syndromes//Syndrome, Fragile X//Syndromes, Fragile X//Marker X Syndrome//Marker X Syndromes//Syndrome, Marker X//Syndromes, Marker X//Mental Retardation, X-Linked, Associated With Marxq28//X-Linked Mental Retardation and Macroorchidism//X Linked Mental Retardation and Macroorchidism//Fragile X Mental Retardation Syndrome//Martin-Bell Syndrome//Martin Bell Syndrome//Syndrome, Martin-Bell//Fra(X) Syndrome//FRAXE Syndrome//FRAXE Syndromes//Syndrome, FRAXE//Syndromes, FRAXE//Mental Retardation, X-Linked, Associated With Fragile Site Fraxe//Fragile X-F Mental Retardation Syndrome//Mar (X) Syndrome//FRAXA Syndrome//FRAXA Syndromes//Syndrome, FRAXA//Syndromes, FRAXA

Expression Detail

GEO ID: GSE83556 Description: Global transcriptome dysregulation in second trimester fetuses with FMR1 expansions Experimental Design: Disease vs Control Case Disease Type: Fragile X Syndrome Case Disease SubType: NA Case Sample: Fragile X Syndrome Control Sample: Normal Number of Case: 22 Number of Control: 18 Number of Samples: 40

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ABCF1 chr6 30571393 30597179 + ABHD13 chr13 108218392 108234243 + ABI2 chr2 203328239 203447728 + ABL2 chr1 179099330 179229684 - AC093525.2 chr16 2496032 2520218 + AC138894.1 chr16 28456371 28492098 - ACD chr16 67657512 67660815 - ACIN1 chr14 23058564 23095614 - ACTB chr7 5527148 5563784 - ADORA2A chr22 24417879 24442357 + AFG3L2 chr18 12328944 12377227 - AGAP3 chr7 151085831 151144436 + AGO2 chr8 140520156 140635633 - AHCY chr20 34280268 34311802 - AK7 chr14 96392128 96489427 + AKAP13 chr15 85380571 85749358 + AL138752.2 chr9 37588413 38068687 - AL139300.1 chr14 103562962 103685924 + AL357673.1 chr1 54132686 54200073 - AL513165.2 chr9 37512547 37592469 - ALCAM chr3 105366909 105576900 + miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-3620-3p chr1 228097320 228097341 + hsa-miR-5100 chr10 42997630 42997651 + circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand A1BG-AS1 chr19 58347718 58355455 + AC109460.3 chr16 28974804 28990775 + AD000090.1 chr19 35557956 35581954 + AL096870.2 chr14 24209646 24215987 - AL137127.1 chr1 19072110 19075511 - Display:

Experiment Detail

GEO ID: GSE83556 Sample Source: Amniotic Fluid Source Fraction: Supernatant Platform: GPL570 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 17063 Sample treatment protocol: RNA was extracted from 5-15 mL amniotic fluid supernatant (centrifugation at 350g, 4C, 10, min). RNA Extract protocol: All samples were processed using the Qiagen Circulating Nucleic Acid kit with an on-column DNase digestion step to remove genomic DNA. The RNA was then purified and concentrated with the RNeasy MinElute Clean up kit and eluted in RNasefree water. RNA library preparation protocol: RNA was converted to cDNA and amplified using the Ovation Pico WTA kit V2 and then purified with the QIAquick PCR Purification kit. Samples were labeled using the Encore Biotin Module (NuGEN, San Carlos, CA)Samples were labeled using the Encore Biotin Module (NuGEN, San Carlos, CA).

Reference

PMID: NA Title: NA Author: NA Journal: NA Description: NA