exRNAdisease

Entry Detail

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General Information

Database ID: exR0087300 RNA Name: hsa-miR-1181 RNA Type: miRNA Chromosome: chr19 Starnd: - Coordinate: Start Site(bp): 10403505 End Site(bp): 10403525 External Links: hsa-miR-1181

Disease Information

Disease Name: Moyamoya Disease Disease Category: Nervous System Diseases MeSH ID: D009072 Type: Diseases Category/Nervous System Diseases Alias: Progressive Intracranial Occlusive Arteropathy (Moyamoya)//Moyamoya Syndrome//Moya-Moya Disease//Disease, Moya-Moya//Moya Moya Disease//Cerebrovascular Moyamoya Disease//Moyamoya Disease, Primary//Disease, Primary Moyamoya//Moyamoya Diseases, Primary//Primary Moyamoya Disease//Primary Moyamoya Diseases//Moyamoya Disease, Classic//Classic Moyamoya Disease//Disease, Classic Moyamoya//Moyamoya Disease, Secondary//Secondary Moyamoya Disease

Expression Detail

GEO ID: GSE100488 Description: Circulating miRNome profiling in Moyamoya disease-discordant monozygotic twins Experimental Design: Disease vs Control Case Disease Type: Moyamoya Disease Case Disease SubType: NA Case Sample: Moyamoya Disease Control Sample: Normal Number of Case: 11 Number of Control: 10 Number of Samples: 21

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand CDC37 chr19 10391133 10420121 - CHD7 chr8 60678740 60868028 + IRS2 chr13 109752695 109786583 - MAZ chr16 29806106 29811164 + PIM1 chr6 37170152 37175428 + RRP1B chr21 43659560 43696079 + ZMIZ1 chr10 79068966 79316528 + CAMK4 chr5 111223653 111494886 + ELF1 chr13 40931924 41061440 - GNAS chr20 58839718 58911192 + GSPT1 chr16 11868128 11916082 - HNRNPA0 chr5 137745651 137754363 - HNRNPUL2 chr11 62712630 62727457 - HNRNPUL2-BSCL2 chr11 62690275 62727384 - IMMT chr2 86143932 86195770 - MDFIC chr7 114922154 115019202 + PRKAA2 chr1 56645314 56715335 + RAB21 chr12 71754863 71800286 + RALY chr20 33993646 34108308 + SLC4A4 chr4 71062667 71572087 + SOX1 chr13 112067149 112071706 + SPINT2 chr19 38244035 38292615 + TMEFF1 chr9 100473149 100577636 + TTC3 chr21 37073226 37203112 + U2AF1 chr21 43092956 43107587 - U2AF1L5 chr21 6484623 6499261 - UBE2D2 chr5 139526431 139628434 + ZNF282 chr7 149195546 149226238 + miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC007216.1 chr16 11976851 11977850 - Display:

Experiment Detail

GEO ID: GSE100488 Sample Source: Blood Source Fraction: Plasma Platform: GPL20712 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 291 Sample treatment protocol: Whole blood samples were collected into disodium ethylenediaminotetraacetate tubes, centrifuged (4 °C, 3000 rpm, 30 minutes) immediately for plasma. RNA Extract protocol: Total RNA was isolated from 200 uL of the pooled plasma using miRNeasy Serum/Plasma Kit (QIAGEN, Hilden, Germany). RNA library preparation protocol: Cyanine 3-pCp-labeled microRNA was prepared from 2-uL of total RNA isolated from 200-uL of plasma, using Agilent's miRNA Complete Labeling and Hyb Kit (part number 5190-0456).

Reference

PMID: 30157848 Title: Circulating miRNome profiling in Moyamoya disease-discordant monozygotic twins and endothelial microRNA expression analysis using iPS cell line Author: Uchino H, Ito M, Kazumata K, Hama Y, Hamauchi S, Terasaka S, Sasaki H, Houkin K Journal: BMC Med Genomics. 2018 Aug 29;11(1):72. Description: we employed a disease discordant monozygotic twin-based study design to unmask potential confounders.