exRNAdisease

Entry Detail

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General Information

Database ID: exR0087329 RNA Name: hsa-miR-146a-5p RNA Type: miRNA Chromosome: chr5 Starnd: + Coordinate: Start Site(bp): 160485372 End Site(bp): 160485393 External Links: hsa-miR-146a-5p

Disease Information

Disease Name: Moyamoya Disease Disease Category: Nervous System Diseases MeSH ID: D009072 Type: Diseases Category/Nervous System Diseases Alias: Progressive Intracranial Occlusive Arteropathy (Moyamoya)//Moyamoya Syndrome//Moya-Moya Disease//Disease, Moya-Moya//Moya Moya Disease//Cerebrovascular Moyamoya Disease//Moyamoya Disease, Primary//Disease, Primary Moyamoya//Moyamoya Diseases, Primary//Primary Moyamoya Disease//Primary Moyamoya Diseases//Moyamoya Disease, Classic//Classic Moyamoya Disease//Disease, Classic Moyamoya//Moyamoya Disease, Secondary//Secondary Moyamoya Disease

Expression Detail

GEO ID: GSE100488 Description: Circulating miRNome profiling in Moyamoya disease-discordant monozygotic twins Experimental Design: Disease vs Control Case Disease Type: Moyamoya Disease Case Disease SubType: NA Case Sample: Moyamoya Disease Control Sample: Normal Number of Case: 11 Number of Control: 10 Number of Samples: 21

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ALDOA chr16 30064164 30070457 + ATP6V0D1 chr16 67438014 67481181 - FXYD3 chr19 35115879 35124324 + GATAD1 chr7 92447482 92460075 + HYOU1 chr11 119044188 119057227 - JPT2 chr16 1678256 1702280 + NFIX chr19 12995608 13098796 + RNF169 chr11 74748849 74842413 + SKA2 chr17 59109857 59155260 - SS18 chr18 26016253 26091217 - TACC1 chr8 38728186 38853028 + WDR45B chr17 82614562 82648553 - ZNF512B chr20 63956704 63969930 - ZNRF3 chr22 28883572 29057488 + APEH chr3 49674014 49683971 + DCAF1 chr3 51395867 51500002 - GNAS chr20 58839718 58911192 + HSP90AA1 chr14 102080738 102139699 - KDM1A chr1 23019443 23083689 + MARCKS chr6 113857345 113863475 + NDUFS2 chr1 161197104 161214395 + RBBP7 chrX 16839283 16870414 - RPL9 chr4 39452521 39458949 - SAP18 chr13 21140514 21149084 + SLC25A5 chrX 119468422 119471396 + SPAG5 chr17 28577565 28599025 - miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0000418 chr12 69983264 69985939 + hsa_circ_0001361 chr3 171830241 171851336 + hsa_circ_0000943 chr19 47421744 47440665 + hsa_circ_0000799 chr17 65941524 65972074 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand KCNQ1OT1 chr11 2608328 2699994 - MALAT1 chr11 65497688 65506516 + NEAT1 chr11 65422774 65445540 + SNHG16 chr17 76557764 76565348 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE100488 Sample Source: Blood Source Fraction: Plasma Platform: GPL20712 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 291 Sample treatment protocol: Whole blood samples were collected into disodium ethylenediaminotetraacetate tubes, centrifuged (4 °C, 3000 rpm, 30 minutes) immediately for plasma. RNA Extract protocol: Total RNA was isolated from 200 uL of the pooled plasma using miRNeasy Serum/Plasma Kit (QIAGEN, Hilden, Germany). RNA library preparation protocol: Cyanine 3-pCp-labeled microRNA was prepared from 2-uL of total RNA isolated from 200-uL of plasma, using Agilent's miRNA Complete Labeling and Hyb Kit (part number 5190-0456).

Reference

PMID: 30157848 Title: Circulating miRNome profiling in Moyamoya disease-discordant monozygotic twins and endothelial microRNA expression analysis using iPS cell line Author: Uchino H, Ito M, Kazumata K, Hama Y, Hamauchi S, Terasaka S, Sasaki H, Houkin K Journal: BMC Med Genomics. 2018 Aug 29;11(1):72. Description: we employed a disease discordant monozygotic twin-based study design to unmask potential confounders.