Entry Detail



General Information

Database ID:exR0087333
RNA Name:hsa-miR-15a-5p
RNA Type:miRNA
Chromosome:chr13
Starnd:-
Coordinate:
Start Site(bp):50049167End Site(bp):50049188
External Links:hsa-miR-15a-5p



Disease Information

Disease Name:Moyamoya Disease
Disease Category:Nervous System Diseases
MeSH ID:D009072
Type:Diseases Category/Nervous System Diseases
Alias:Progressive Intracranial Occlusive Arteropathy (Moyamoya)//Moyamoya Syndrome//Moya-Moya Disease//Disease, Moya-Moya//Moya Moya Disease//Cerebrovascular Moyamoya Disease//Moyamoya Disease, Primary//Disease, Primary Moyamoya//Moyamoya Diseases, Primary//Primary Moyamoya Disease//Primary Moyamoya Diseases//Moyamoya Disease, Classic//Classic Moyamoya Disease//Disease, Classic Moyamoya//Moyamoya Disease, Secondary//Secondary Moyamoya Disease



Expression Detail

GEO ID:GSE100488
Description:Circulating miRNome profiling in Moyamoya disease-discordant monozygotic twins
Experimental Design:Disease vs Control
Case Disease Type:Moyamoya Disease
Case Disease SubType:NA
Case Sample:Moyamoya Disease
Control Sample:Normal
Number of Case:11
Number of Control:10
Number of Samples:21





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
SPRYD3
chr12
53064316
53079404
-
FAM89A
chr1
231018958
231040254
-
ZNF664
chr12
123971845
124015439
+
ABCF3
chr3
184186023
184194012
+
LITAF
chr16
11547722
11636381
-
GPR107
chr9
130053426
130140169
+
CTTNBP2
chr7
117710651
117874139
-
MED11
chr17
4731428
4733607
+
ABHD2
chr15
89087459
89202355
+
UNC119B
chr12
120710458
120723640
+
AADAT
chr4
170060222
170091699
-
KLHDC3
chr6
43014103
43021298
+
JARID2
chr6
15246069
15522042
+
ITPR1
chr3
4493345
4847840
+
MAPK1IP1L
chr14
55051647
55070194
+
ANKRD17
chr4
73073376
73258798
-
SRPK1
chr6
35832966
35921342
-
STEAP3
chr2
119223831
119265652
+
AMER1
chrX
64185117
64205708
-
ASB1
chr2
238426742
238452250
+
ARL1
chr12
101393116
101407772
-
MRPS2
chr9
135499984
135504673
+
SCAMP4
chr19
1905372
1926013
+
ATXN7L3
chr17
44191805
44200113
-
ZBTB34
chr9
126860665
126885878
+
PLPP6
chr9
4662294
4665258
+
ERG28
chr14
75649791
75660876
-
TSPYL2
chrX
53082367
53088540
+
ADGRL1
chr19
14147743
14206187
-
TBL1X
chrX
9463295
9741037
+
miRNA targets:NA
circRNA targets:
circRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa_circ_0000540
chr14
55799534
55821940
+
hsa_circ_0001005
chr2
53921020
53978078
-
hsa_circ_0001723
chr7
91924202
91948826
+
hsa_circ_0000458
chr12
124071293
124074996
+
hsa_circ_0001699
chr7
40027197
40041630
+
hsa_circ_0001387
chr4
1902352
1936989
+
hsa_circ_0001168
chr20
47691321
47707559
+
hsa_circ_0000552
chr14
71880664
71948928
+
hsa_circ_0000038
chr1
28800065
28802803
+
hsa_circ_0000652
chr15
90984737
90986710
+
hsa_circ_0001472
chr5
36953719
36976504
+
hsa_circ_0001263
chr3
5215701
5216099
+
hsa_circ_0000799
chr17
65941524
65972074
+
hsa_circ_0001164
chr20
45891031
45923523
-
hsa_circ_0000032
chr1
25666964
25669564
+
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
XIST
chrX
73820649
73852723
-
NEAT1
chr11
65422774
65445540
+
NUTM2A-AS1
chr10
87201647
87342612
-
AC021078.1
chr5
149494314
149504670
-
SNHG25
chr17
64145970
64146476
+
AC079781.5
chr7
97851688
97972985
-
LINC02035
chr3
122886941
122892416
+
LINC00662
chr19
27681072
27794005
-
AL359924.1
chr1
237862175
237928321
+
FGD5-AS1
chr3
14920347
14948424
-
AC009022.1
chr16
69976297
70065948
-
AC114980.1
chr5
93860669
93863825
-
MZF1-AS1
chr19
58559129
58574797
+
AL031282.2
chr1
1702736
1737688
-
AC003092.1
chr7
94022833
94066661
+
AC020978.7
chr16
68224713
68227734
+
MIR497HG
chr17
7015818
7019659
-
AP000317.2
chr21
34073592
34360033
+
AC002470.2
chr22
20979462
20998121
+
HCG18
chr6
30286690
30327382
-
MIR503HG
chrX
134543119
134546642
-
SNHG12
chr1
28578538
28583132
-
NUTM2B-AS1
chr10
79661394
79826594
-
LINC00649
chr21
33915534
33977691
+
AC021092.1
chr19
44103007
44113183
-
SNHG16
chr17
76557764
76565348
+
SNHG1
chr11
62851984
62855953
-
STAG3L5P-PVRIG2P-PILRB
chr7
100336104
100367831
+
MCM3AP-AS1
chr21
46229196
46259390
+
MIR29B2CHG
chr1
207801518
207879115
-
Display:



Experiment Detail

GEO ID:GSE100488
Sample Source:Blood
Source Fraction:Plasma
Platform:GPL20712
Method:Microarray
Num of detected RNA Type:1
Num of detected RNAs of this Type:291
Sample treatment protocol:Whole blood samples were collected into disodium ethylenediaminotetraacetate tubes, centrifuged (4 °C, 3000 rpm, 30 minutes) immediately for plasma.
RNA Extract protocol:Total RNA was isolated from 200 uL of the pooled plasma using miRNeasy Serum/Plasma Kit (QIAGEN, Hilden, Germany).
RNA library preparation protocol:Cyanine 3-pCp-labeled microRNA was prepared from 2-uL of total RNA isolated from 200-uL of plasma, using Agilent's miRNA Complete Labeling and Hyb Kit (part number 5190-0456).



Reference

PMID:30157848
Title:Circulating miRNome profiling in Moyamoya disease-discordant monozygotic twins and endothelial microRNA expression analysis using iPS cell line
Author:Uchino H, Ito M, Kazumata K, Hama Y, Hamauchi S, Terasaka S, Sasaki H, Houkin K
Journal:BMC Med Genomics. 2018 Aug 29;11(1):72.
Description:we employed a disease discordant monozygotic twin-based study design to unmask potential confounders.