exRNAdisease

Entry Detail

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General Information

Database ID: exR0087334 RNA Name: hsa-miR-15b-5p RNA Type: miRNA Chromosome: chr3 Starnd: + Coordinate: Start Site(bp): 160404607 End Site(bp): 160404628 External Links: hsa-miR-15b-5p

Disease Information

Disease Name: Moyamoya Disease Disease Category: Nervous System Diseases MeSH ID: D009072 Type: Diseases Category/Nervous System Diseases Alias: Progressive Intracranial Occlusive Arteropathy (Moyamoya)//Moyamoya Syndrome//Moya-Moya Disease//Disease, Moya-Moya//Moya Moya Disease//Cerebrovascular Moyamoya Disease//Moyamoya Disease, Primary//Disease, Primary Moyamoya//Moyamoya Diseases, Primary//Primary Moyamoya Disease//Primary Moyamoya Diseases//Moyamoya Disease, Classic//Classic Moyamoya Disease//Disease, Classic Moyamoya//Moyamoya Disease, Secondary//Secondary Moyamoya Disease

Expression Detail

GEO ID: GSE100488 Description: Circulating miRNome profiling in Moyamoya disease-discordant monozygotic twins Experimental Design: Disease vs Control Case Disease Type: Moyamoya Disease Case Disease SubType: NA Case Sample: Moyamoya Disease Control Sample: Normal Number of Case: 11 Number of Control: 10 Number of Samples: 21

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand URM1 chr9 128371361 128392016 + STEAP3 chr2 119223831 119265652 + ABCF3 chr3 184186023 184194012 + RAB11FIP1 chr8 37858618 37899497 - FAM89A chr1 231018958 231040254 - LITAF chr16 11547722 11636381 - ZBTB34 chr9 126860665 126885878 + LY6E chr8 143017982 143023832 + ATG14 chr14 55366391 55411830 - MINDY2 chr15 58771192 58861900 + MRPS2 chr9 135499984 135504673 + DCAF7 chr17 63550477 63594279 + ANKRD17 chr4 73073376 73258798 - JARID2 chr6 15246069 15522042 + RAPGEF1 chr9 131576770 131740074 - MLEC chr12 120687149 120701859 + FAM102B chr1 108560089 108644900 + ARRDC4 chr15 97960703 97973833 + ERG28 chr14 75649791 75660876 - CRY2 chr11 45847118 45883248 + TSPYL2 chrX 53082367 53088540 + E2F3 chr6 20401879 20493714 + ABHD2 chr15 89087459 89202355 + PIK3R1 chr5 68215756 68301821 + MED11 chr17 4731428 4733607 + SCAMP4 chr19 1905372 1926013 + SRPK1 chr6 35832966 35921342 - FLOT2 chr17 28879335 28897733 - MYB chr6 135181308 135219173 + HDGF chr1 156742109 156766925 - miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0000540 chr14 55799534 55821940 + hsa_circ_0001005 chr2 53921020 53978078 - hsa_circ_0001723 chr7 91924202 91948826 + hsa_circ_0000458 chr12 124071293 124074996 + hsa_circ_0001699 chr7 40027197 40041630 + hsa_circ_0001387 chr4 1902352 1936989 + hsa_circ_0001168 chr20 47691321 47707559 + hsa_circ_0000552 chr14 71880664 71948928 + hsa_circ_0000038 chr1 28800065 28802803 + hsa_circ_0000652 chr15 90984737 90986710 + hsa_circ_0001472 chr5 36953719 36976504 + hsa_circ_0001263 chr3 5215701 5216099 + hsa_circ_0000799 chr17 65941524 65972074 + hsa_circ_0001164 chr20 45891031 45923523 - hsa_circ_0000032 chr1 25666964 25669564 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand LINC00649 chr21 33915534 33977691 + AL031282.2 chr1 1702736 1737688 - MZF1-AS1 chr19 58559129 58574797 + SNHG16 chr17 76557764 76565348 + XIST chrX 73820649 73852723 - STAG3L5P-PVRIG2P-PILRB chr7 100336104 100367831 + NUTM2B-AS1 chr10 79661394 79826594 - MCM3AP-AS1 chr21 46229196 46259390 + AL391244.1 chr1 1420245 1422691 + AC003092.1 chr7 94022833 94066661 + AC114980.1 chr5 93860669 93863825 - AC079781.5 chr7 97851688 97972985 - AC021092.1 chr19 44103007 44113183 - AC009022.1 chr16 69976297 70065948 - AL359924.1 chr1 237862175 237928321 + FGD5-AS1 chr3 14920347 14948424 - MIR497HG chr17 7015818 7019659 - AC021078.1 chr5 149494314 149504670 - LINC01184 chr5 127939152 128083172 - NEAT1 chr11 65422774 65445540 + SNHG1 chr11 62851984 62855953 - AC002470.2 chr22 20979462 20998121 + MIR29B2CHG chr1 207801518 207879115 - LINC00662 chr19 27681072 27794005 - MIR503HG chrX 134543119 134546642 - SNHG25 chr17 64145970 64146476 + LINC02035 chr3 122886941 122892416 + NUTM2A-AS1 chr10 87201647 87342612 - HCG18 chr6 30286690 30327382 - SNHG12 chr1 28578538 28583132 - Display:

Experiment Detail

GEO ID: GSE100488 Sample Source: Blood Source Fraction: Plasma Platform: GPL20712 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 291 Sample treatment protocol: Whole blood samples were collected into disodium ethylenediaminotetraacetate tubes, centrifuged (4 °C, 3000 rpm, 30 minutes) immediately for plasma. RNA Extract protocol: Total RNA was isolated from 200 uL of the pooled plasma using miRNeasy Serum/Plasma Kit (QIAGEN, Hilden, Germany). RNA library preparation protocol: Cyanine 3-pCp-labeled microRNA was prepared from 2-uL of total RNA isolated from 200-uL of plasma, using Agilent's miRNA Complete Labeling and Hyb Kit (part number 5190-0456).

Reference

PMID: 30157848 Title: Circulating miRNome profiling in Moyamoya disease-discordant monozygotic twins and endothelial microRNA expression analysis using iPS cell line Author: Uchino H, Ito M, Kazumata K, Hama Y, Hamauchi S, Terasaka S, Sasaki H, Houkin K Journal: BMC Med Genomics. 2018 Aug 29;11(1):72. Description: we employed a disease discordant monozygotic twin-based study design to unmask potential confounders.