exRNAdisease

Entry Detail

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General Information

Database ID: exR0087346 RNA Name: hsa-miR-19a-3p RNA Type: miRNA Chromosome: chr13 Starnd: + Coordinate: Start Site(bp): 91350939 End Site(bp): 91350961 External Links: hsa-miR-19a-3p

Disease Information

Disease Name: Moyamoya Disease Disease Category: Nervous System Diseases MeSH ID: D009072 Type: Diseases Category/Nervous System Diseases Alias: Progressive Intracranial Occlusive Arteropathy (Moyamoya)//Moyamoya Syndrome//Moya-Moya Disease//Disease, Moya-Moya//Moya Moya Disease//Cerebrovascular Moyamoya Disease//Moyamoya Disease, Primary//Disease, Primary Moyamoya//Moyamoya Diseases, Primary//Primary Moyamoya Disease//Primary Moyamoya Diseases//Moyamoya Disease, Classic//Classic Moyamoya Disease//Disease, Classic Moyamoya//Moyamoya Disease, Secondary//Secondary Moyamoya Disease

Expression Detail

GEO ID: GSE100488 Description: Circulating miRNome profiling in Moyamoya disease-discordant monozygotic twins Experimental Design: Disease vs Control Case Disease Type: Moyamoya Disease Case Disease SubType: NA Case Sample: Moyamoya Disease Control Sample: Normal Number of Case: 11 Number of Control: 10 Number of Samples: 21

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ATP6V1B2 chr8 20197381 20226819 + BCL7A chr12 122019422 122062044 + BRWD1 chr21 39184176 39321559 - BTBD7 chr14 93237550 93333092 - CAMTA1 chr1 6785454 7769706 + CASP2 chr7 143288215 143307696 + CCDC47 chr17 63745255 63776351 - DNAJC16 chr1 15526813 15592379 + HIP1 chr7 75533298 75738962 - HOMER1 chr5 79372636 79514134 - MEF2D chr1 156463727 156500779 - MYLIP chr6 16129086 16148248 + RCOR1 chr14 102592649 102730561 + RFX1 chr19 13961530 14007039 - RPS23 chr5 82273320 82278396 - TMEM181 chr6 158536436 158635428 + ATF7IP chr12 14365632 14502935 + CAMSAP1 chr9 135808487 135907546 - CDS1 chr4 84583127 84651334 + CHIC1 chrX 73563200 73687102 + DTL chr1 212035553 212107400 + MARCKS chr6 113857345 113863475 + SCYL2 chr12 100267140 100341715 + SPAG7 chr17 4959226 4967817 - SPOPL chr2 138501770 138573547 + STK33 chr11 8391868 8594289 - TNFRSF12A chr16 3018445 3022383 + miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0001454 chr4 154524454 154533552 + hsa_circ_0001186 chr21 35475133 35475818 + hsa_circ_0000384 chr12 27867712 27877119 + hsa_circ_0001605 chr6 42903447 42905047 + hsa_circ_0000155 chr1 168007608 168014465 + hsa_circ_0001495 chr5 68470703 68471364 + hsa_circ_0000943 chr19 47421744 47440665 + hsa_circ_0001164 chr20 45891031 45923523 - lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC005394.2 chr19 28435388 28727680 - AC010997.3 chr10 75279726 75401246 - AC011498.2 chr19 4447304 4448217 + AC011503.2 chr19 23927788 23929287 + AC021078.1 chr5 149494314 149504670 - AC135050.6 chr16 31122235 31124064 + AL049840.4 chr14 103694516 103695050 - AL158206.1 chr9 19453209 19455173 + AL158825.2 chr9 75009828 75016036 - H19 chr11 1995176 2001470 - HAGLR chr2 176164051 176188958 - LAMTOR5-AS1 chr1 110347116 110443817 + LINC00667 chr18 5237826 5290608 + MCM3AP-AS1 chr21 46229196 46259390 + NEAT1 chr11 65422774 65445540 + SNHG20 chr17 77086716 77099902 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE100488 Sample Source: Blood Source Fraction: Plasma Platform: GPL20712 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 291 Sample treatment protocol: Whole blood samples were collected into disodium ethylenediaminotetraacetate tubes, centrifuged (4 °C, 3000 rpm, 30 minutes) immediately for plasma. RNA Extract protocol: Total RNA was isolated from 200 uL of the pooled plasma using miRNeasy Serum/Plasma Kit (QIAGEN, Hilden, Germany). RNA library preparation protocol: Cyanine 3-pCp-labeled microRNA was prepared from 2-uL of total RNA isolated from 200-uL of plasma, using Agilent's miRNA Complete Labeling and Hyb Kit (part number 5190-0456).

Reference

PMID: 30157848 Title: Circulating miRNome profiling in Moyamoya disease-discordant monozygotic twins and endothelial microRNA expression analysis using iPS cell line Author: Uchino H, Ito M, Kazumata K, Hama Y, Hamauchi S, Terasaka S, Sasaki H, Houkin K Journal: BMC Med Genomics. 2018 Aug 29;11(1):72. Description: we employed a disease discordant monozygotic twin-based study design to unmask potential confounders.