exRNAdisease

Entry Detail

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General Information

Database ID: exR0087349 RNA Name: hsa-miR-20b-5p RNA Type: miRNA Chromosome: chrX Starnd: - Coordinate: Start Site(bp): 134169850 End Site(bp): 134169872 External Links: hsa-miR-20b-5p

Disease Information

Disease Name: Moyamoya Disease Disease Category: Nervous System Diseases MeSH ID: D009072 Type: Diseases Category/Nervous System Diseases Alias: Progressive Intracranial Occlusive Arteropathy (Moyamoya)//Moyamoya Syndrome//Moya-Moya Disease//Disease, Moya-Moya//Moya Moya Disease//Cerebrovascular Moyamoya Disease//Moyamoya Disease, Primary//Disease, Primary Moyamoya//Moyamoya Diseases, Primary//Primary Moyamoya Disease//Primary Moyamoya Diseases//Moyamoya Disease, Classic//Classic Moyamoya Disease//Disease, Classic Moyamoya//Moyamoya Disease, Secondary//Secondary Moyamoya Disease

Expression Detail

GEO ID: GSE100488 Description: Circulating miRNome profiling in Moyamoya disease-discordant monozygotic twins Experimental Design: Disease vs Control Case Disease Type: Moyamoya Disease Case Disease SubType: NA Case Sample: Moyamoya Disease Control Sample: Normal Number of Case: 11 Number of Control: 10 Number of Samples: 21

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand RIT1 chr1 155897808 155911404 - CHD2 chr15 92900189 93027996 + ARMC8 chr3 138187248 138298384 + MAGI3 chr1 113390515 113685923 + RPUSD3 chr3 9837849 9844602 - KLF3 chr4 38664197 38701517 + CYLD chr16 50742050 50801935 + WASF3 chr13 26557683 26688948 + PLEKHM1 chr17 45435900 45490749 - ATXN1 chr6 16299112 16761491 - NSD2 chr4 1871393 1982207 + CHD9 chr16 53055033 53329150 + STRIP1 chr1 110031577 110074641 + FCF1 chr14 74713144 74738620 + SMYD3 chr1 245749342 246507312 - PXYLP1 chr3 141228726 141367753 + DNAJC27 chr2 24943636 24972094 - EEF2 chr19 3976056 3985463 - AMPD2 chr1 109616104 109632053 + LONP2 chr16 48244300 48363122 + C9orf40 chr9 74946583 74952912 - NAA16 chr13 41311267 41377030 + CRCP chr7 66114604 66154568 + CUL1 chr7 148697914 148801110 + MTHFR chr1 11785723 11806455 - PXDN chr2 1631887 1744852 - ZNF468 chr19 52838010 52857649 - EAPP chr14 34515938 34539711 - IKZF2 chr2 212999691 213152427 - SENP1 chr12 48042897 48106079 - miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0001495 chr5 68470703 68471364 + hsa_circ_0000494 chr13 76134888 76143643 + hsa_circ_0000018 chr1 15860731 15863309 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC015871.3 chr15 79920195 79922455 - AC021078.1 chr5 149494314 149504670 - AC021092.1 chr19 44103007 44113183 - AC024940.6 chr12 31280422 31280895 - AC084082.1 chr8 66112667 66126632 + AC087477.2 chr15 96354237 96405235 + AC243964.3 chr19 44631573 44725217 - AL031428.1 chr1 23020147 23088058 - AL137782.1 chr13 75549773 75807120 + AL158206.1 chr9 19453209 19455173 + AL161772.1 chr13 20699307 20703718 - ARHGAP27P1-BPTFP1-KPNA2P3 chr17 64749663 64781707 - CKMT2-AS1 chr5 81201341 81301565 - EPB41L4A-AS1 chr5 112160526 112164818 + ERICD chr8 140636281 140638283 + FGD5-AS1 chr3 14920347 14948424 - H19 chr11 1995176 2001470 - HAGLR chr2 176164051 176188958 - HOTAIR chr12 53962308 53974956 - MALAT1 chr11 65497688 65506516 + NEAT1 chr11 65422774 65445540 + NORAD chr20 36045618 36051018 - SNHG16 chr17 76557764 76565348 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE100488 Sample Source: Blood Source Fraction: Plasma Platform: GPL20712 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 291 Sample treatment protocol: Whole blood samples were collected into disodium ethylenediaminotetraacetate tubes, centrifuged (4 °C, 3000 rpm, 30 minutes) immediately for plasma. RNA Extract protocol: Total RNA was isolated from 200 uL of the pooled plasma using miRNeasy Serum/Plasma Kit (QIAGEN, Hilden, Germany). RNA library preparation protocol: Cyanine 3-pCp-labeled microRNA was prepared from 2-uL of total RNA isolated from 200-uL of plasma, using Agilent's miRNA Complete Labeling and Hyb Kit (part number 5190-0456).

Reference

PMID: 30157848 Title: Circulating miRNome profiling in Moyamoya disease-discordant monozygotic twins and endothelial microRNA expression analysis using iPS cell line Author: Uchino H, Ito M, Kazumata K, Hama Y, Hamauchi S, Terasaka S, Sasaki H, Houkin K Journal: BMC Med Genomics. 2018 Aug 29;11(1):72. Description: we employed a disease discordant monozygotic twin-based study design to unmask potential confounders.