exRNAdisease

Entry Detail

---



General Information

Database ID: exR0087350 RNA Name: hsa-miR-21-5p RNA Type: miRNA Chromosome: chr17 Starnd: + Coordinate: Start Site(bp): 59841273 End Site(bp): 59841294 External Links: hsa-miR-21-5p

Disease Information

Disease Name: Moyamoya Disease Disease Category: Nervous System Diseases MeSH ID: D009072 Type: Diseases Category/Nervous System Diseases Alias: Progressive Intracranial Occlusive Arteropathy (Moyamoya)//Moyamoya Syndrome//Moya-Moya Disease//Disease, Moya-Moya//Moya Moya Disease//Cerebrovascular Moyamoya Disease//Moyamoya Disease, Primary//Disease, Primary Moyamoya//Moyamoya Diseases, Primary//Primary Moyamoya Disease//Primary Moyamoya Diseases//Moyamoya Disease, Classic//Classic Moyamoya Disease//Disease, Classic Moyamoya//Moyamoya Disease, Secondary//Secondary Moyamoya Disease

Expression Detail

GEO ID: GSE100488 Description: Circulating miRNome profiling in Moyamoya disease-discordant monozygotic twins Experimental Design: Disease vs Control Case Disease Type: Moyamoya Disease Case Disease SubType: NA Case Sample: Moyamoya Disease Control Sample: Normal Number of Case: 11 Number of Control: 10 Number of Samples: 21

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand KAZN chr1 13892792 15118043 + UBE2T chr1 202331657 202341980 - CLEC2D chr12 9664969 9699553 + EIF4A2 chr3 186783205 186789897 + MGST1 chr12 16347142 16609259 + POLE3 chr9 113407235 113410675 - SOWAHC chr2 109614364 109618990 + OSER1 chr20 44195939 44210771 - EXOC4 chr7 133253073 134066589 + EDARADD chr1 236348257 236502915 + HNRNPA0 chr5 137745651 137754363 - GPSM3 chr6 32190766 32195523 - CTH chr1 70411218 70439851 + CITED2 chr6 139371807 139374648 - MTREX chr5 55307989 55425579 + AP3D1 chr19 2100988 2164468 - ELP2 chr18 36129444 36180557 + HSPA4 chr5 133052013 133106449 + RGS1 chr1 192575763 192580024 + HSD17B4 chr5 119452473 119637199 + ZFP36L1 chr14 68787660 68796253 - HMGA1 chr6 34236873 34246231 + EEF1B2 chr2 206159585 206162928 + DYNC1H1 chr14 101964573 102056443 + DUSP2 chr2 96143169 96145440 - MCRS1 chr12 49556544 49568145 - ATRX chrX 77504878 77786233 - ZADH2 chr18 75195113 75209139 - PLIN2 chr9 19108375 19149290 - TREX1 chr3 48465811 48467645 + miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0001731 chr7 100731990 100738448 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC068768.1 chr12 123262060 123262402 + ARHGAP27P1-BPTFP1-KPNA2P3 chr17 64749663 64781707 - OTUD6B-AS1 chr8 91059318 91070583 - SNHG1 chr11 62851984 62855953 - TUG1 chr22 30969245 30979395 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE100488 Sample Source: Blood Source Fraction: Plasma Platform: GPL20712 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 291 Sample treatment protocol: Whole blood samples were collected into disodium ethylenediaminotetraacetate tubes, centrifuged (4 °C, 3000 rpm, 30 minutes) immediately for plasma. RNA Extract protocol: Total RNA was isolated from 200 uL of the pooled plasma using miRNeasy Serum/Plasma Kit (QIAGEN, Hilden, Germany). RNA library preparation protocol: Cyanine 3-pCp-labeled microRNA was prepared from 2-uL of total RNA isolated from 200-uL of plasma, using Agilent's miRNA Complete Labeling and Hyb Kit (part number 5190-0456).

Reference

PMID: 30157848 Title: Circulating miRNome profiling in Moyamoya disease-discordant monozygotic twins and endothelial microRNA expression analysis using iPS cell line Author: Uchino H, Ito M, Kazumata K, Hama Y, Hamauchi S, Terasaka S, Sasaki H, Houkin K Journal: BMC Med Genomics. 2018 Aug 29;11(1):72. Description: we employed a disease discordant monozygotic twin-based study design to unmask potential confounders.