exRNAdisease

Entry Detail

---



General Information

Database ID: exR0087380 RNA Name: hsa-miR-3652 RNA Type: miRNA Chromosome: chr12 Starnd: + Coordinate: Start Site(bp): 103930425 End Site(bp): 103930442 External Links: hsa-miR-3652

Disease Information

Disease Name: Moyamoya Disease Disease Category: Nervous System Diseases MeSH ID: D009072 Type: Diseases Category/Nervous System Diseases Alias: Progressive Intracranial Occlusive Arteropathy (Moyamoya)//Moyamoya Syndrome//Moya-Moya Disease//Disease, Moya-Moya//Moya Moya Disease//Cerebrovascular Moyamoya Disease//Moyamoya Disease, Primary//Disease, Primary Moyamoya//Moyamoya Diseases, Primary//Primary Moyamoya Disease//Primary Moyamoya Diseases//Moyamoya Disease, Classic//Classic Moyamoya Disease//Disease, Classic Moyamoya//Moyamoya Disease, Secondary//Secondary Moyamoya Disease

Expression Detail

GEO ID: GSE100488 Description: Circulating miRNome profiling in Moyamoya disease-discordant monozygotic twins Experimental Design: Disease vs Control Case Disease Type: Moyamoya Disease Case Disease SubType: NA Case Sample: Moyamoya Disease Control Sample: Normal Number of Case: 11 Number of Control: 10 Number of Samples: 21

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ATP5MC3 chr2 175176258 175184607 - GANAB chr11 62624826 62646726 - HDLBP chr2 241227264 241317061 - PGRMC1 chrX 119236245 119244466 + PTMA chr2 231706895 231713541 + RAB15 chr14 64945814 64973226 - AC099811.2 chr17 42119674 42154916 - AP2A1 chr19 49766968 49807113 + AP2M1 chr3 184174689 184184091 + ARHGAP33 chr19 35774532 35788822 + BDNF chr11 27654893 27722058 - BRI3 chr7 98252379 98310441 + CCT6A chr7 56051685 56063989 + FKBP8 chr19 18531751 18544077 - GATC chr12 120446444 120463749 + GDF11 chr12 55743122 55757264 + HLA-DRA chr6 32439878 32445046 + HSP90B1 chr12 103930107 103953645 + MIB2 chr1 1615415 1630610 + RAB5C chr17 42124976 42155044 - SF3A2 chr19 2236824 2248655 + SFPQ chr1 35176378 35193145 - WASF1 chr6 110099819 110180004 - WBP11 chr12 14784582 14803486 - miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC022819.1 chr15 99157231 99161140 - AL591742.2 chr1 114032393 114034511 + Display:

Experiment Detail

GEO ID: GSE100488 Sample Source: Blood Source Fraction: Plasma Platform: GPL20712 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 291 Sample treatment protocol: Whole blood samples were collected into disodium ethylenediaminotetraacetate tubes, centrifuged (4 °C, 3000 rpm, 30 minutes) immediately for plasma. RNA Extract protocol: Total RNA was isolated from 200 uL of the pooled plasma using miRNeasy Serum/Plasma Kit (QIAGEN, Hilden, Germany). RNA library preparation protocol: Cyanine 3-pCp-labeled microRNA was prepared from 2-uL of total RNA isolated from 200-uL of plasma, using Agilent's miRNA Complete Labeling and Hyb Kit (part number 5190-0456).

Reference

PMID: 30157848 Title: Circulating miRNome profiling in Moyamoya disease-discordant monozygotic twins and endothelial microRNA expression analysis using iPS cell line Author: Uchino H, Ito M, Kazumata K, Hama Y, Hamauchi S, Terasaka S, Sasaki H, Houkin K Journal: BMC Med Genomics. 2018 Aug 29;11(1):72. Description: we employed a disease discordant monozygotic twin-based study design to unmask potential confounders.