Entry Detail



General Information

Database ID:exR0087403
RNA Name:hsa-miR-4433a-5p
RNA Type:miRNA
Chromosome:chr2
Starnd:+
Coordinate:
Start Site(bp):64340770End Site(bp):64340790
External Links:hsa-miR-4433a-5p



Disease Information

Disease Name:Moyamoya Disease
Disease Category:Nervous System Diseases
MeSH ID:D009072
Type:Diseases Category/Nervous System Diseases
Alias:Progressive Intracranial Occlusive Arteropathy (Moyamoya)//Moyamoya Syndrome//Moya-Moya Disease//Disease, Moya-Moya//Moya Moya Disease//Cerebrovascular Moyamoya Disease//Moyamoya Disease, Primary//Disease, Primary Moyamoya//Moyamoya Diseases, Primary//Primary Moyamoya Disease//Primary Moyamoya Diseases//Moyamoya Disease, Classic//Classic Moyamoya Disease//Disease, Classic Moyamoya//Moyamoya Disease, Secondary//Secondary Moyamoya Disease



Expression Detail

GEO ID:GSE100488
Description:Circulating miRNome profiling in Moyamoya disease-discordant monozygotic twins
Experimental Design:Disease vs Control
Case Disease Type:Moyamoya Disease
Case Disease SubType:NA
Case Sample:Moyamoya Disease
Control Sample:Normal
Number of Case:11
Number of Control:10
Number of Samples:21





Regulatory Relationship

mRNA targets:NA
miRNA targets:NA
circRNA targets:NA
lncRNA targets:NA
Display:N/A



Experiment Detail

GEO ID:GSE100488
Sample Source:Blood
Source Fraction:Plasma
Platform:GPL20712
Method:Microarray
Num of detected RNA Type:1
Num of detected RNAs of this Type:291
Sample treatment protocol:Whole blood samples were collected into disodium ethylenediaminotetraacetate tubes, centrifuged (4 °C, 3000 rpm, 30 minutes) immediately for plasma.
RNA Extract protocol:Total RNA was isolated from 200 uL of the pooled plasma using miRNeasy Serum/Plasma Kit (QIAGEN, Hilden, Germany).
RNA library preparation protocol:Cyanine 3-pCp-labeled microRNA was prepared from 2-uL of total RNA isolated from 200-uL of plasma, using Agilent's miRNA Complete Labeling and Hyb Kit (part number 5190-0456).



Reference

PMID:30157848
Title:Circulating miRNome profiling in Moyamoya disease-discordant monozygotic twins and endothelial microRNA expression analysis using iPS cell line
Author:Uchino H, Ito M, Kazumata K, Hama Y, Hamauchi S, Terasaka S, Sasaki H, Houkin K
Journal:BMC Med Genomics. 2018 Aug 29;11(1):72.
Description:we employed a disease discordant monozygotic twin-based study design to unmask potential confounders.