exRNAdisease

Entry Detail

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General Information

Database ID: exR0093380 RNA Name: hsa-miR-302e RNA Type: miRNA Chromosome: chr11 Starnd: + Coordinate: Start Site(bp): 7234771 End Site(bp): 7234787 External Links: hsa-miR-302e

Disease Information

Disease Name: Benign Ovarian Disease Disease Category: Urogenital Diseases and Pregnancy Complications MeSH ID: D010049 Type: Diseases Category/Female Urogenital Diseases and Pregnancy Complications Alias: Ovarian Diseases//Disease, Ovarian//Diseases, Ovarian//Ovarian Disease

Expression Detail

GEO ID: GSE106817 Description: Integrated extracellular microRNA profiling for ovarian cancer screening Experimental Design: Cancer vs Control Case Disease Type: Benign Ovarian Disease Case Disease SubType: NA Case Sample: Benign Ovarian Disease Control Sample: Non-Cancer Number of Case: 29 Number of Control: 2759 Number of Samples: 2788

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ATP6V1B2 chr8 20197381 20226819 + BTN3A1 chr6 26402237 26415208 + CCSAP chr1 229321011 229343294 - CELF2 chr10 10798397 11336675 + CLCN6 chr1 11806096 11848079 + COL4A2 chr13 110305812 110513209 + CUL1 chr7 148697914 148801110 + KMT5B chr11 68154863 68213828 - MTMR12 chr5 32226994 32312987 - OCRL chrX 129539849 129592561 + PFN2 chr3 149964904 150050788 - PLAGL2 chr20 32192504 32207743 - PLEKHM1 chr17 45435900 45490749 - SEC16A chr9 136440096 136483759 - SLC7A2 chr8 17497088 17570573 + SYAP1 chrX 16719612 16765340 + TARDBP chr1 11012344 11026420 + TRIB1 chr8 125430358 125438403 + TXNIP chr1 145992435 145996579 - WASF3 chr13 26557683 26688948 + miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0000943 chr19 47421744 47440665 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AL049840.4 chr14 103694516 103695050 - ARHGAP27P1-BPTFP1-KPNA2P3 chr17 64749663 64781707 - FGD5-AS1 chr3 14920347 14948424 - MIR17HG chr13 91347820 91354579 + NEAT1 chr11 65422774 65445540 + SNHG16 chr17 76557764 76565348 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE106817 Sample Source: Blood Source Fraction: Serum Platform: GPL21263 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2535 Sample treatment protocol: NA RNA Extract protocol: Total RNA was extracted each from 300uL serum samples using 3D-Gene® RNA extraction reagent from liquid sample kit (Toray Industries, Inc.). RNA library preparation protocol: miRNA was labeled using 3D-Gene® miRNA Labeling kit in accordance with the manufacturer's instructions.

Reference

PMID: 30333487 Title: Integrated extracellular microRNA profiling for ovarian cancer screening Author: Yokoi A, Matsuzaki J, Yamamoto Y, Yoneoka Y, Takahashi K, Shimizu H, Uehara T, Ishikawa M, Ikeda SI, Sonoda T, Kawauchi J, Takizawa S, Aoki Y, Niida S, Sakamoto H, Kato K, Kato T, Ochiya T Journal: Nat Commun. 2018 Oct 17;9(1):4319. Description: to develop an optimal detection method, we use microarrays to obtain comprehensive miRNA profiles from 4046 serum samples, including 428 patients with ovarian tumors.