Entry Detail


General Information

Database ID:exR0153376
RNA Name:hsa-miR-198
RNA Type:miRNA
Chromosome:chr3
Starnd:-
Coordinate:
Start Site(bp):120395703End Site(bp):120395724
External Links:hsa-miR-198



Disease Information

Disease Name:Prostate Cancer
Disease Category:Cancers
MeSH ID:D011471
Type:Neoplasms/Digestive System Neoplasms
Alias:Prostatic Neoplasms//Prostate Neoplasms//Neoplasms, Prostate//Neoplasm, Prostate//Prostate Neoplasm//Neoplasms, Prostatic//Neoplasm, Prostatic//Prostatic Neoplasm//Prostate Cancer//Cancer, Prostate//Cancers, Prostate//Prostate Cancers//Cancer of the Prostate//Prostatic Cancer//Cancer, Prostatic//Cancers, Prostatic//Prostatic Cancers//Cancer of Prostate



Expression Detail

GEO ID:GSE113234
Description:Circulating microRNAs combined with PSA for an accurate and non-invasive prostate cancer detection
Experimental Design:Cancer vs Control
Case Disease Type:Prostate Cancer
Case Disease SubType:NA
Case Sample:Prostate Cancer
Control Sample:Healthy
Number of Case:60
Number of Control:27
Number of Samples:87





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
C18orf25
chr18
46173553
46266992
+
CGN
chr1
151510510
151538692
+
CS
chr12
56271699
56300391
-
FSTL1
chr3
120392293
120450993
-
UBE2K
chr4
39698109
39782792
+
CCDC103
chr17
44899142
44905390
+
CLTC
chr17
59619689
59696956
+
FAM187A
chr17
44899712
44905390
+
LRRC20
chr10
70298970
70382650
-
MAP1B
chr5
72107234
72209565
+
NECTIN2
chr19
44846175
44889223
+
RRP7A
chr22
42508344
42519796
-
TPGS2
chr18
36777647
36829216
-
TUBA1A
chr12
49184795
49189080
-
ZNF281
chr1
200404940
200410056
-
miRNA targets:NA
circRNA targets:NA
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
FTX
chrX
73940435
74293574
-
Display:



Experiment Detail

GEO ID:GSE113234
Sample Source:Blood
Source Fraction:Plasma
Platform:GPL19730
Method:Microarray
Num of detected RNA Type:1
Num of detected RNAs of this Type:1972
Sample treatment protocol:NA
RNA Extract protocol:Extraction was performed using miRNEasy serum/plasma kit from Qiagen.
RNA library preparation protocol:Briefly, 4 ul of totRNA were dephosphorylated and denaturated; then a ligation and labeling step with Cy3 was performed



Reference

PMID:30452625
Title:Circulating microRNAs combined with PSA for accurate and non-invasive prostate cancer detection
Author:Mello-Grand M, Gregnanin I, Sacchetto L, Ostano P, Zitella A, Bottoni G, Oderda M, Marra G, Munegato S, Pardini B, Naccarati A, Gasparini M, Gontero P, Chiorino G
Journal:Carcinogenesis. 2019 Apr 29;40(2):246-253.
Description:we propose to combine circulating microRNAs (miRs) with PSA, to improve the diagnostic route for PCa