exRNAdisease

Entry Detail

---



General Information

Database ID: exR0155585 RNA Name: hsa-miR-3173-5p RNA Type: miRNA Chromosome: chr14 Starnd: - Coordinate: Start Site(bp): 95137961 End Site(bp): 95137982 External Links: hsa-miR-3173-5p

Disease Information

Disease Name: Benign Prostatic Hyperplasia Disease Category: Urogenital Diseases and Pregnancy Complications MeSH ID: D011470 Type: Diseases Category/Male Urogenital Diseases Alias: Prostatic Hyperplasia//Hyperplasia, Prostatic//Prostatic Hypertrophy//Adenoma, Prostatic//Adenomas, Prostatic//Prostatic Adenomas//Prostatic Adenoma//Benign Prostatic Hyperplasia//Prostatic Hyperplasia, Benign//Prostatic Hypertrophy, Benign//Benign Prostatic Hypertrophy//Hypertrophy, Benign Prostatic

Expression Detail

GEO ID: GSE113234 Description: Circulating microRNAs combined with PSA for an accurate and non-invasive prostate cancer detection Experimental Design: Cancer vs Control Case Disease Type: Prostate Cancer Case Disease SubType: NA Case Sample: Benign Prostatic Hyperplasia Control Sample: Healthy Number of Case: 60 Number of Control: 27 Number of Samples: 87

Regulatory Relationship

mRNA targets: NA miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0001731 chr7 100731990 100738448 + hsa_circ_0001387 chr4 1902352 1936989 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC004069.1 chr4 105137280 105140619 - AC009065.4 chr16 2119207 2120248 + AL160006.1 chr1 110058340 110062555 + AL355987.2 chr9 136800366 136829466 + H19 chr11 1995176 2001470 - KCNQ1OT1 chr11 2608328 2699994 - LINC00894 chrX 149938613 150224580 + MIR17HG chr13 91347820 91354579 + MIR194-2HG chr11 64889560 64893449 - NEAT1 chr11 65422774 65445540 + SNHG22 chr18 49814023 49851059 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE113234 Sample Source: Blood Source Fraction: Plasma Platform: GPL19730 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 1972 Sample treatment protocol: NA RNA Extract protocol: Extraction was performed using miRNEasy serum/plasma kit from Qiagen. RNA library preparation protocol: Briefly, 4 ul of totRNA were dephosphorylated and denaturated; then a ligation and labeling step with Cy3 was performed

Reference

PMID: 30452625 Title: Circulating microRNAs combined with PSA for accurate and non-invasive prostate cancer detection Author: Mello-Grand M, Gregnanin I, Sacchetto L, Ostano P, Zitella A, Bottoni G, Oderda M, Marra G, Munegato S, Pardini B, Naccarati A, Gasparini M, Gontero P, Chiorino G Journal: Carcinogenesis. 2019 Apr 29;40(2):246-253. Description: we propose to combine circulating microRNAs (miRs) with PSA, to improve the diagnostic route for PCa