exRNAdisease

Entry Detail

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General Information

Database ID: exR0155637 RNA Name: hsa-miR-324-3p RNA Type: miRNA Chromosome: chr17 Starnd: - Coordinate: Start Site(bp): 7223308 End Site(bp): 7223330 External Links: hsa-miR-324-3p

Disease Information

Disease Name: Benign Prostatic Hyperplasia Disease Category: Urogenital Diseases and Pregnancy Complications MeSH ID: D011470 Type: Diseases Category/Male Urogenital Diseases Alias: Prostatic Hyperplasia//Hyperplasia, Prostatic//Prostatic Hypertrophy//Adenoma, Prostatic//Adenomas, Prostatic//Prostatic Adenomas//Prostatic Adenoma//Benign Prostatic Hyperplasia//Prostatic Hyperplasia, Benign//Prostatic Hypertrophy, Benign//Benign Prostatic Hypertrophy//Hypertrophy, Benign Prostatic

Expression Detail

GEO ID: GSE113234 Description: Circulating microRNAs combined with PSA for an accurate and non-invasive prostate cancer detection Experimental Design: Cancer vs Control Case Disease Type: Prostate Cancer Case Disease SubType: NA Case Sample: Benign Prostatic Hyperplasia Control Sample: Healthy Number of Case: 60 Number of Control: 27 Number of Samples: 87

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ACLY chr17 41866917 41930542 - ATXN7L3 chr17 44191805 44200113 - CDC42EP2 chr11 65314866 65322417 + CELSR2 chr1 109249539 109275751 + DBNDD1 chr16 90004871 90020128 - DCAF15 chr19 13952492 13961449 + FBXL19 chr16 30923055 30948783 + LNPEP chr5 96935394 97037513 + MAPKAPK2 chr1 206684944 206734283 + MXD4 chr4 2247432 2262109 - NACC1 chr19 13116862 13141147 + PDRG1 chr20 31944337 31952046 - SMAD7 chr18 48919853 48952052 - SPTBN2 chr11 66685248 66729226 - SYVN1 chr11 65121780 65134533 - TAGLN chr11 117199370 117207464 + TNFRSF10B chr8 23020133 23069031 - TULP4 chr6 158232236 158511828 + miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0001727 chr7 99621041 99621930 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC040162.3 chr16 67882461 67886367 + AC234582.1 chr1 155195004 155205495 + KCNQ1OT1 chr11 2608328 2699994 - LINC01521 chr22 31346777 31348719 + MALAT1 chr11 65497688 65506516 + NEAT1 chr11 65422774 65445540 + NORAD chr20 36045618 36051018 - SNHG22 chr18 49814023 49851059 + Display:

Experiment Detail

GEO ID: GSE113234 Sample Source: Blood Source Fraction: Plasma Platform: GPL19730 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 1972 Sample treatment protocol: NA RNA Extract protocol: Extraction was performed using miRNEasy serum/plasma kit from Qiagen. RNA library preparation protocol: Briefly, 4 ul of totRNA were dephosphorylated and denaturated; then a ligation and labeling step with Cy3 was performed

Reference

PMID: 30452625 Title: Circulating microRNAs combined with PSA for accurate and non-invasive prostate cancer detection Author: Mello-Grand M, Gregnanin I, Sacchetto L, Ostano P, Zitella A, Bottoni G, Oderda M, Marra G, Munegato S, Pardini B, Naccarati A, Gasparini M, Gontero P, Chiorino G Journal: Carcinogenesis. 2019 Apr 29;40(2):246-253. Description: we propose to combine circulating microRNAs (miRs) with PSA, to improve the diagnostic route for PCa