exRNAdisease

Entry Detail

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General Information

Database ID: exR0155658 RNA Name: hsa-miR-33b-5p RNA Type: miRNA Chromosome: chr17 Starnd: - Coordinate: Start Site(bp): 17813897 End Site(bp): 17813916 External Links: hsa-miR-33b-5p

Disease Information

Disease Name: Benign Prostatic Hyperplasia Disease Category: Urogenital Diseases and Pregnancy Complications MeSH ID: D011470 Type: Diseases Category/Male Urogenital Diseases Alias: Prostatic Hyperplasia//Hyperplasia, Prostatic//Prostatic Hypertrophy//Adenoma, Prostatic//Adenomas, Prostatic//Prostatic Adenomas//Prostatic Adenoma//Benign Prostatic Hyperplasia//Prostatic Hyperplasia, Benign//Prostatic Hypertrophy, Benign//Benign Prostatic Hypertrophy//Hypertrophy, Benign Prostatic

Expression Detail

GEO ID: GSE113234 Description: Circulating microRNAs combined with PSA for an accurate and non-invasive prostate cancer detection Experimental Design: Cancer vs Control Case Disease Type: Prostate Cancer Case Disease SubType: NA Case Sample: Benign Prostatic Hyperplasia Control Sample: Healthy Number of Case: 60 Number of Control: 27 Number of Samples: 87

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ADCY9 chr16 3953387 4116442 - AFF4 chr5 132875395 132963634 - BTBD7 chr14 93237550 93333092 - CERK chr22 46684410 46738252 - CROT chr7 87345681 87399795 + DDX5 chr17 64498254 64508199 - E2F3 chr6 20401879 20493714 + ECHDC1 chr6 127288712 127343609 - EIF5A2 chr3 170888418 170908644 - IGF1R chr15 98648539 98964530 + IRS2 chr13 109752695 109786583 - MAPK1IP1L chr14 55051647 55070194 + MAPK6 chr15 51952106 52067375 + MTHFD2 chr2 74198610 74217565 + MYO19 chr17 36495633 36543435 - NAA15 chr4 139301505 139420033 + NFAT5 chr16 69565094 69704666 + PIM1 chr6 37170152 37175428 + RBM33 chr7 155644451 155781485 + RCAN1 chr21 34513142 34615113 - ROBO1 chr3 78597239 79767998 - SLC39A8 chr4 102251041 102431258 - SULF2 chr20 47656348 47786616 - TNPO1 chr5 72816312 72916733 + TPM1 chr15 63042632 63071915 + UBN2 chr7 139230356 139308236 + WDFY3 chr4 84669610 84966391 - XRN1 chr3 142306607 142448062 - ZFYVE16 chr5 80408013 80483379 + ZNF148 chr3 125225561 125375354 - miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0000540 chr14 55799534 55821940 + hsa_circ_0001349 chr3 152132729 152150709 + hsa_circ_0000642 chr15 80390757 80415142 + hsa_circ_0000643 chr15 80412669 80415142 + hsa_circ_0000284 chr11 33307958 33309057 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC023509.1 chr12 53441741 53467528 + DANCR chr4 52712404 52720351 + FGD5-AS1 chr3 14920347 14948424 - MCF2L-AS1 chr13 112967484 112968824 - NEAT1 chr11 65422774 65445540 + Display:

Experiment Detail

GEO ID: GSE113234 Sample Source: Blood Source Fraction: Plasma Platform: GPL19730 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 1972 Sample treatment protocol: NA RNA Extract protocol: Extraction was performed using miRNEasy serum/plasma kit from Qiagen. RNA library preparation protocol: Briefly, 4 ul of totRNA were dephosphorylated and denaturated; then a ligation and labeling step with Cy3 was performed

Reference

PMID: 30452625 Title: Circulating microRNAs combined with PSA for accurate and non-invasive prostate cancer detection Author: Mello-Grand M, Gregnanin I, Sacchetto L, Ostano P, Zitella A, Bottoni G, Oderda M, Marra G, Munegato S, Pardini B, Naccarati A, Gasparini M, Gontero P, Chiorino G Journal: Carcinogenesis. 2019 Apr 29;40(2):246-253. Description: we propose to combine circulating microRNAs (miRs) with PSA, to improve the diagnostic route for PCa