exRNAdisease

Entry Detail

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General Information

Database ID: exR0155713 RNA Name: hsa-miR-3654 RNA Type: miRNA Chromosome: chr7 Starnd: - Coordinate: Start Site(bp): 133034860 End Site(bp): 133034878 External Links: hsa-miR-3654

Disease Information

Disease Name: Benign Prostatic Hyperplasia Disease Category: Urogenital Diseases and Pregnancy Complications MeSH ID: D011470 Type: Diseases Category/Male Urogenital Diseases Alias: Prostatic Hyperplasia//Hyperplasia, Prostatic//Prostatic Hypertrophy//Adenoma, Prostatic//Adenomas, Prostatic//Prostatic Adenomas//Prostatic Adenoma//Benign Prostatic Hyperplasia//Prostatic Hyperplasia, Benign//Prostatic Hypertrophy, Benign//Benign Prostatic Hypertrophy//Hypertrophy, Benign Prostatic

Expression Detail

GEO ID: GSE113234 Description: Circulating microRNAs combined with PSA for an accurate and non-invasive prostate cancer detection Experimental Design: Cancer vs Control Case Disease Type: Prostate Cancer Case Disease SubType: NA Case Sample: Benign Prostatic Hyperplasia Control Sample: Healthy Number of Case: 60 Number of Control: 27 Number of Samples: 87

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand TUBB chr6 30720352 30725426 + DEPDC1B chr5 60596912 60700190 - ERI2 chr16 20780193 20900349 - CCT7 chr2 73233420 73253021 + APLP2 chr11 130068147 130144811 + MRPL11 chr11 66435075 66466738 - HSPA8 chr11 123057489 123063230 - GGH chr8 63015079 63038806 - MDK chr11 46380756 46383837 + EGR1 chr5 138465479 138469303 + MKRN1 chr7 140453033 140479536 - RPS14 chr5 150442635 150449739 - DDTL chr22 23966888 23972556 + DCAF8 chr1 160215715 160262549 - RNPS1 chr16 2253116 2268397 - DCPS chr11 126304060 126350005 + MPRIP chr17 17042545 17217679 + RPL12 chr9 127447674 127451406 - RPL13A chr19 49487554 49492308 + RPS12 chr6 132814569 132817564 + HLA-DRA chr6 32439878 32445046 + STMN1 chr1 25884181 25906991 - RPS3 chr11 75399515 75422280 + RPL3 chr22 39312882 39320389 - FTH1 chr11 61959718 61967634 - TSPAN18 chr11 44726465 44932423 + HLA-DRB5 chr6 32517353 32530287 - NOLC1 chr10 102152176 102163871 + HMGA1 chr6 34236873 34246231 + CCDC85C chr14 99500190 99604207 - miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AD000090.1 chr19 35557956 35581954 + BCDIN3D-AS1 chr12 49827913 49841143 + LINC00996 chr7 150433654 150448140 + Display:

Experiment Detail

GEO ID: GSE113234 Sample Source: Blood Source Fraction: Plasma Platform: GPL19730 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 1972 Sample treatment protocol: NA RNA Extract protocol: Extraction was performed using miRNEasy serum/plasma kit from Qiagen. RNA library preparation protocol: Briefly, 4 ul of totRNA were dephosphorylated and denaturated; then a ligation and labeling step with Cy3 was performed

Reference

PMID: 30452625 Title: Circulating microRNAs combined with PSA for accurate and non-invasive prostate cancer detection Author: Mello-Grand M, Gregnanin I, Sacchetto L, Ostano P, Zitella A, Bottoni G, Oderda M, Marra G, Munegato S, Pardini B, Naccarati A, Gasparini M, Gontero P, Chiorino G Journal: Carcinogenesis. 2019 Apr 29;40(2):246-253. Description: we propose to combine circulating microRNAs (miRs) with PSA, to improve the diagnostic route for PCa