exRNAdisease

Entry Detail

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General Information

Database ID: exR0156118 RNA Name: hsa-miR-455-5p RNA Type: miRNA Chromosome: chr9 Starnd: + Coordinate: Start Site(bp): 114209449 End Site(bp): 114209470 External Links: hsa-miR-455-5p

Disease Information

Disease Name: Benign Prostatic Hyperplasia Disease Category: Urogenital Diseases and Pregnancy Complications MeSH ID: D011470 Type: Diseases Category/Male Urogenital Diseases Alias: Prostatic Hyperplasia//Hyperplasia, Prostatic//Prostatic Hypertrophy//Adenoma, Prostatic//Adenomas, Prostatic//Prostatic Adenomas//Prostatic Adenoma//Benign Prostatic Hyperplasia//Prostatic Hyperplasia, Benign//Prostatic Hypertrophy, Benign//Benign Prostatic Hypertrophy//Hypertrophy, Benign Prostatic

Expression Detail

GEO ID: GSE113234 Description: Circulating microRNAs combined with PSA for an accurate and non-invasive prostate cancer detection Experimental Design: Cancer vs Control Case Disease Type: Prostate Cancer Case Disease SubType: NA Case Sample: Benign Prostatic Hyperplasia Control Sample: Healthy Number of Case: 60 Number of Control: 27 Number of Samples: 87

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand AEN chr15 88621337 88632281 + BCL3 chr19 44747705 44760044 + CANT1 chr17 78991716 79009867 - NAPA chr19 47487637 47515091 - NRIP1 chr21 14961235 15065936 - RCCD1 chr15 90954870 90963125 + REEP4 chr8 22138020 22141951 - RGS4 chr1 163068775 163076802 + UBE2K chr4 39698109 39782792 + VCL chr10 73995193 74121363 + WDR5B chr3 122411846 122416062 - ZBTB34 chr9 126860665 126885878 + ZNF10 chr12 133130575 133159465 + miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC020928.2 chr19 36773712 36775908 - AL034397.3 chrX 66015461 66020422 + GAS5 chr1 173858559 173868882 - KCNQ1OT1 chr11 2608328 2699994 - MALAT1 chr11 65497688 65506516 + NEAT1 chr11 65422774 65445540 + NORAD chr20 36045618 36051018 - Display:

Experiment Detail

GEO ID: GSE113234 Sample Source: Blood Source Fraction: Plasma Platform: GPL19730 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 1972 Sample treatment protocol: NA RNA Extract protocol: Extraction was performed using miRNEasy serum/plasma kit from Qiagen. RNA library preparation protocol: Briefly, 4 ul of totRNA were dephosphorylated and denaturated; then a ligation and labeling step with Cy3 was performed

Reference

PMID: 30452625 Title: Circulating microRNAs combined with PSA for accurate and non-invasive prostate cancer detection Author: Mello-Grand M, Gregnanin I, Sacchetto L, Ostano P, Zitella A, Bottoni G, Oderda M, Marra G, Munegato S, Pardini B, Naccarati A, Gasparini M, Gontero P, Chiorino G Journal: Carcinogenesis. 2019 Apr 29;40(2):246-253. Description: we propose to combine circulating microRNAs (miRs) with PSA, to improve the diagnostic route for PCa