exRNAdisease

Entry Detail

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General Information

Database ID: exR0156238 RNA Name: hsa-miR-4707-5p RNA Type: miRNA Chromosome: chr14 Starnd: - Coordinate: Start Site(bp): 22956998 End Site(bp): 22957020 External Links: hsa-miR-4707-5p

Disease Information

Disease Name: Benign Prostatic Hyperplasia Disease Category: Urogenital Diseases and Pregnancy Complications MeSH ID: D011470 Type: Diseases Category/Male Urogenital Diseases Alias: Prostatic Hyperplasia//Hyperplasia, Prostatic//Prostatic Hypertrophy//Adenoma, Prostatic//Adenomas, Prostatic//Prostatic Adenomas//Prostatic Adenoma//Benign Prostatic Hyperplasia//Prostatic Hyperplasia, Benign//Prostatic Hypertrophy, Benign//Benign Prostatic Hypertrophy//Hypertrophy, Benign Prostatic

Expression Detail

GEO ID: GSE113234 Description: Circulating microRNAs combined with PSA for an accurate and non-invasive prostate cancer detection Experimental Design: Cancer vs Control Case Disease Type: Prostate Cancer Case Disease SubType: NA Case Sample: Benign Prostatic Hyperplasia Control Sample: Healthy Number of Case: 60 Number of Control: 27 Number of Samples: 87

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand SLC35B2 chr6 44254096 44257890 - TXN2 chr22 36467046 36481640 - AC138811.2 chr16 18788063 18801519 - HAUS4 chr14 22946228 22957161 - MGME1 chr20 17969018 17991122 + RPLP1 chr15 69452814 69456205 + RPS15A chr16 18781295 18790383 - RPS9 chr19 54200809 54249003 + TUBA1B chr12 49127782 49131397 - WRNIP1 chr6 2765393 2786952 + miRNA targets: NA circRNA targets: NA lncRNA targets: NA Display:

Experiment Detail

GEO ID: GSE113234 Sample Source: Blood Source Fraction: Plasma Platform: GPL19730 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 1972 Sample treatment protocol: NA RNA Extract protocol: Extraction was performed using miRNEasy serum/plasma kit from Qiagen. RNA library preparation protocol: Briefly, 4 ul of totRNA were dephosphorylated and denaturated; then a ligation and labeling step with Cy3 was performed

Reference

PMID: 30452625 Title: Circulating microRNAs combined with PSA for accurate and non-invasive prostate cancer detection Author: Mello-Grand M, Gregnanin I, Sacchetto L, Ostano P, Zitella A, Bottoni G, Oderda M, Marra G, Munegato S, Pardini B, Naccarati A, Gasparini M, Gontero P, Chiorino G Journal: Carcinogenesis. 2019 Apr 29;40(2):246-253. Description: we propose to combine circulating microRNAs (miRs) with PSA, to improve the diagnostic route for PCa