Entry Detail


General Information

Database ID:exR0156642
RNA Name:hsa-miR-556-5p
RNA Type:miRNA
Chromosome:chr1
Starnd:+
Coordinate:
Start Site(bp):162342561End Site(bp):162342582
External Links:hsa-miR-556-5p



Disease Information

Disease Name:Benign Prostatic Hyperplasia
Disease Category:Urogenital Diseases and Pregnancy Complications
MeSH ID:D011470
Type:Diseases Category/Male Urogenital Diseases
Alias:Prostatic Hyperplasia//Hyperplasia, Prostatic//Prostatic Hypertrophy//Adenoma, Prostatic//Adenomas, Prostatic//Prostatic Adenomas//Prostatic Adenoma//Benign Prostatic Hyperplasia//Prostatic Hyperplasia, Benign//Prostatic Hypertrophy, Benign//Benign Prostatic Hypertrophy//Hypertrophy, Benign Prostatic



Expression Detail

GEO ID:GSE113234
Description:Circulating microRNAs combined with PSA for an accurate and non-invasive prostate cancer detection
Experimental Design:Cancer vs Control
Case Disease Type:Prostate Cancer
Case Disease SubType:NA
Case Sample:Benign Prostatic Hyperplasia
Control Sample:Healthy
Number of Case:60
Number of Control:27
Number of Samples:87





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
MXD1
chr2
69897688
69942945
+
OSR2
chr8
98944403
98952104
+
SOX13
chr1
204073115
204127743
+
miRNA targets:NA
circRNA targets:
circRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa_circ_0001673
chr7
6085701
6089676
-
hsa_circ_0000711
chr16
68155889
68160513
+
hsa_circ_0001168
chr20
47691321
47707559
+
hsa_circ_0000799
chr17
65941524
65972074
+
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC020978.7
chr16
68224713
68227734
+
AC023509.1
chr12
53441741
53467528
+
AL355075.4
chr14
20343048
20343685
-
KCNQ1OT1
chr11
2608328
2699994
-
LINC00265
chr7
39733430
39793092
+
NEAT1
chr11
65422774
65445540
+
SNHG1
chr11
62851984
62855953
-
Display:



Experiment Detail

GEO ID:GSE113234
Sample Source:Blood
Source Fraction:Plasma
Platform:GPL19730
Method:Microarray
Num of detected RNA Type:1
Num of detected RNAs of this Type:1972
Sample treatment protocol:NA
RNA Extract protocol:Extraction was performed using miRNEasy serum/plasma kit from Qiagen.
RNA library preparation protocol:Briefly, 4 ul of totRNA were dephosphorylated and denaturated; then a ligation and labeling step with Cy3 was performed



Reference

PMID:30452625
Title:Circulating microRNAs combined with PSA for accurate and non-invasive prostate cancer detection
Author:Mello-Grand M, Gregnanin I, Sacchetto L, Ostano P, Zitella A, Bottoni G, Oderda M, Marra G, Munegato S, Pardini B, Naccarati A, Gasparini M, Gontero P, Chiorino G
Journal:Carcinogenesis. 2019 Apr 29;40(2):246-253.
Description:we propose to combine circulating microRNAs (miRs) with PSA, to improve the diagnostic route for PCa