Entry Detail


General Information

Database ID:exR0156886
RNA Name:hsa-miR-654-3p
RNA Type:miRNA
Chromosome:chr14
Starnd:+
Coordinate:
Start Site(bp):101040269End Site(bp):101040290
External Links:hsa-miR-654-3p



Disease Information

Disease Name:Benign Prostatic Hyperplasia
Disease Category:Urogenital Diseases and Pregnancy Complications
MeSH ID:D011470
Type:Diseases Category/Male Urogenital Diseases
Alias:Prostatic Hyperplasia//Hyperplasia, Prostatic//Prostatic Hypertrophy//Adenoma, Prostatic//Adenomas, Prostatic//Prostatic Adenomas//Prostatic Adenoma//Benign Prostatic Hyperplasia//Prostatic Hyperplasia, Benign//Prostatic Hypertrophy, Benign//Benign Prostatic Hypertrophy//Hypertrophy, Benign Prostatic



Expression Detail

GEO ID:GSE113234
Description:Circulating microRNAs combined with PSA for an accurate and non-invasive prostate cancer detection
Experimental Design:Cancer vs Control
Case Disease Type:Prostate Cancer
Case Disease SubType:NA
Case Sample:Benign Prostatic Hyperplasia
Control Sample:Healthy
Number of Case:60
Number of Control:27
Number of Samples:87





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
ANKRD49
chr11
94493979
94499578
+
ATAD1
chr10
87751512
87841343
-
CAMTA1
chr1
6785454
7769706
+
CLN8
chr8
1755778
1801711
+
EPB41L1
chr20
36091504
36232799
+
RAB10
chr2
26034084
26137454
+
RNF220
chr1
44405194
44651724
+
miRNA targets:NA
circRNA targets:
circRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa_circ_0001146
chr20
34241449
34246936
-
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC005899.4
chr17
32328441
32329395
+
AC079781.5
chr7
97851688
97972985
-
AL049795.2
chr1
32170733
32176568
+
AL358472.3
chr1
153966516
153966930
+
HCG11
chr6
26521709
26527404
+
MCM3AP-AS1
chr21
46229196
46259390
+
NEAT1
chr11
65422774
65445540
+
SNHG1
chr11
62851984
62855953
-
THUMPD3-AS1
chr3
9349689
9398579
-
TUG1
chr22
30969245
30979395
+
XIST
chrX
73820649
73852723
-
ZFAS1
chr20
49278178
49299600
+
Display:



Experiment Detail

GEO ID:GSE113234
Sample Source:Blood
Source Fraction:Plasma
Platform:GPL19730
Method:Microarray
Num of detected RNA Type:1
Num of detected RNAs of this Type:1972
Sample treatment protocol:NA
RNA Extract protocol:Extraction was performed using miRNEasy serum/plasma kit from Qiagen.
RNA library preparation protocol:Briefly, 4 ul of totRNA were dephosphorylated and denaturated; then a ligation and labeling step with Cy3 was performed



Reference

PMID:30452625
Title:Circulating microRNAs combined with PSA for accurate and non-invasive prostate cancer detection
Author:Mello-Grand M, Gregnanin I, Sacchetto L, Ostano P, Zitella A, Bottoni G, Oderda M, Marra G, Munegato S, Pardini B, Naccarati A, Gasparini M, Gontero P, Chiorino G
Journal:Carcinogenesis. 2019 Apr 29;40(2):246-253.
Description:we propose to combine circulating microRNAs (miRs) with PSA, to improve the diagnostic route for PCa