exRNAdisease

Entry Detail

General Information

Database ID:

exR0192519

RNA Name:

hsa-miR-186-5p

RNA Type:

miRNA

Chromosome:

chr1

Starnd:

-

Coordinate:

Start Site(bp):

71067681

End Site(bp):

71067702

External Links:

Disease Information

Disease Name:	Epilepsy
Disease Category:	Nervous System Diseases
MeSH ID:	D004827
Type:	Diseases Category/Nervous System Diseases
Alias:	Epilepsies//Seizure Disorder//Seizure Disorders//Awakening Epilepsy//Epilepsy, Awakening//Epilepsy, Cryptogenic//Cryptogenic Epilepsies//Cryptogenic Epilepsy//Epilepsies, Cryptogenic//Aura//Auras

Expression Detail

GEO ID:	GSE114697
Description:	Dual-center, dual-platform microRNA profiling identifies plasma biomarkers of adult temporal lobe epilepsy (Beaumont)
Experimental Design:	Disease vs Control
Case Disease Type:	Epilepsy
Case Disease SubType:	NA
Case Sample:	Epilepsy
Control Sample:	Control
Number of Case:	32
Number of Control:	16
Number of Samples:	48

Regulatory Relationship

mRNA targets:

Gene Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
DDX3X	chrX	41333284	41364472	+
EP300	chr22	41092592	41180077	+
GPRC5A	chr12	12890782	12917937	+
NRF1	chr7	129611720	129757082	+
TACSTD2	chr1	58575433	58577252	-
TMEM245	chr9	109015135	109119947	-
TNFRSF21	chr6	47231532	47309905	-
TNKS1BP1	chr11	57299638	57324952	-
HMG20A	chr15	77420412	77485607	+
RNF139	chr8	124474738	124487914	+

miRNA targets:

NA

circRNA targets:

circRNA Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
hsa_circ_0000892	chr19	11941431	12014514	+
hsa_circ_0000799	chr17	65941524	65972074	+

lncRNA targets:

lncRNA Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
AC021078.1	chr5	149494314	149504670	-
AC097634.1	chr3	71584943	71587409	+
AC124798.1	chr11	17380649	17383531	+
AC247036.1	chr14	106206603	106208571	+
DLEU2	chr13	49956670	50125720	-
DSCAM-AS1	chr21	40383083	40385358	+
EBLN3P	chr9	37079645	37090928	+
NEAT1	chr11	65422774	65445540	+
OIP5-AS1	chr15	41283990	41309737	+
SNHG3	chr1	28505980	28510892	+
SNHG7	chr9	136721366	136728184	-
TUG1	chr22	30969245	30979395	+
XIST	chrX	73820649	73852723	-

Display:

Experiment Detail

GEO ID:	GSE114697
Sample Source:	Blood
Source Fraction:	Plasma
Platform:	GPL22992
Method:	RT-PCR array
Num of detected RNA Type:	1
Num of detected RNAs of this Type:	78
Sample treatment protocol:	NA
RNA Extract protocol:	Total RNA was extracted from 200 ul of plasma using the miRCURY RNA isolation kit-biofluid (Exiqon).
RNA library preparation protocol:	3 ul of total RNA was processed by reverse transcriptase and mixed with TaqMan OpenArray Real-Time PCR Master mix (1:1).

Reference

PMID:	30396857
Title:	Dual-center, dual-platform microRNA profiling identifies potential plasma biomarkers of adult temporal lobe epilepsy
Author:	Raoof R, Bauer S, El Naggar H, Connolly NMC, Brennan GP, Brindley E, Hill T, McArdle H, Spain E, Forster RJ, Prehn JHM, Hamer H, Delanty N, Rosenow F, Mooney C, Henshall DC
Journal:	EBioMedicine. 2018 Dec;38:127-141.
Description:	Using a case-control design, we collected plasma samples from video-electroencephalogram-monitored adult TLE patients at epilepsy specialist centers in two countries, performed genome-wide PCR-based and RNA sequencing during the discovery phase and validated findings in a large (>) cohort of samples that included patients with psychogenic non-epileptic seizures (PNES)