Entry Detail



General Information

Database ID:exR0201248
RNA Name:hsa-miR-103a-3p
RNA Type:miRNA
Chromosome:chr5
Starnd:-
Coordinate:
Start Site(bp):168560904End Site(bp):168560926
External Links:hsa-miR-103a-3p



Disease Information

Disease Name:Mild Cognitive Impairment
Disease Category:Other Diseases
MeSH ID:D060825
Type:Psychiatry and Psychology Category/Mental Disorders
Alias:Cognitive Dysfunction//Cognitive Dysfunctions//Dysfunction, Cognitive//Dysfunctions, Cognitive//Cognitive Impairments//Cognitive Impairment//Impairment, Cognitive//Impairments, Cognitive//Mild Cognitive Impairment//Cognitive Impairment, Mild//Cognitive Impairments, Mild//Impairment, Mild Cognitive//Impairments, Mild Cognitive//Mild Cognitive Impairments//Mild Neurocognitive Disorder//Disorder, Mild Neurocognitive//Disorders, Mild Neurocognitive//Mild Neurocognitive Disorders//Neurocognitive Disorder, Mild//Neurocognitive Disorders, Mild//Cognitive Decline//Cognitive Declines//Decline, Cognitive//Declines, Cognitive//Mental Deterioration//Deterioration, Mental//Deteriorations, Mental//Mental Deteriorations



Expression Detail

GEO ID:GSE120584
Description:Risk prediction models for dementia constructed by supervised principal component analysis using miRNA expression data
Experimental Design:Disease vs Control
Case Disease Type:Alzheimer's Disease
Case Disease SubType:NA
Case Sample:Mild Cognitive Impairment
Control Sample:Normal
Number of Case:1021
Number of Control:288
Number of Samples:1309





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
RCCD1
chr15
90954870
90963125
+
CA12
chr15
63321378
63381846
-
AMER1
chrX
64185117
64205708
-
PLPP6
chr9
4662294
4665258
+
ERG28
chr14
75649791
75660876
-
SCAMP4
chr19
1905372
1926013
+
DPP3
chr11
66480013
66509657
+
AC011455.2
chr19
38915404
38949855
-
UBN1
chr16
4846665
4882401
+
TMX2
chr11
57712593
57740973
+
RNF157
chr17
76142465
76240493
-
NAA60
chr16
3443649
3486953
+
MRPS2
chr9
135499984
135504673
+
TSPYL2
chrX
53082367
53088540
+
KLHL21
chr1
6590724
6614607
-
TUBA1B
chr12
49127782
49131397
-
STEAP3
chr2
119223831
119265652
+
MRPL3
chr3
131462212
131502983
-
STK16
chr2
219245455
219250337
+
ABCF2
chr7
151207837
151227166
-
RPS6KA3
chrX
20149911
20267519
-
DCAF7
chr17
63550477
63594279
+
CNN2
chr19
1026586
1039068
+
SRPK1
chr6
35832966
35921342
-
ZNF697
chr1
119619377
119648266
-
LYSMD2
chr15
51723011
51751585
-
PODXL
chr7
131500262
131558217
-
EBP
chrX
48521799
48528716
+
RPS14
chr5
150442635
150449739
-
PKM
chr15
72199029
72231822
-
miRNA targets:NA
circRNA targets:
circRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa_circ_0000712
chr16
68208276
68225678
+
hsa_circ_0001723
chr7
91924202
91948826
+
hsa_circ_0001495
chr5
68470703
68471364
+
hsa_circ_0001168
chr20
47691321
47707559
+
hsa_circ_0000652
chr15
90984737
90986710
+
hsa_circ_0001472
chr5
36953719
36976504
+
hsa_circ_0001164
chr20
45891031
45923523
-
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC003092.1
chr7
94022833
94066661
+
AC018521.1
chr17
47945424
47981736
+
AC021078.1
chr5
149494314
149504670
-
AC021092.1
chr19
44103007
44113183
-
AC093297.2
chr5
44826076
44828592
+
AL137127.1
chr1
19072110
19075511
-
FGD5-AS1
chr3
14920347
14948424
-
H19
chr11
1995176
2001470
-
LINC00294
chr11
33076149
33079454
+
LINC00662
chr19
27681072
27794005
-
LINC02035
chr3
122886941
122892416
+
MIR503HG
chrX
134543119
134546642
-
NEAT1
chr11
65422774
65445540
+
NUTM2A-AS1
chr10
87201647
87342612
-
NUTM2B-AS1
chr10
79661394
79826594
-
STAG3L5P-PVRIG2P-PILRB
chr7
100336104
100367831
+
TMEM147-AS1
chr19
35540738
35546029
-
TTC28-AS1
chr22
27919376
28008581
+
TTN-AS1
chr2
178521183
178779963
+
XIST
chrX
73820649
73852723
-
Display:



Experiment Detail

GEO ID:GSE120584
Sample Source:Blood
Source Fraction:Serum
Platform:GPL21263
Method:Microarray
Num of detected RNA Type:1
Num of detected RNAs of this Type:2532
Sample treatment protocol:NA
RNA Extract protocol:Total RNA was extracted each from 300uL serum samples using 3D-Gene® RNA extraction reagent from liquid sample kit (Toray Industries, Inc.).
RNA library preparation protocol:miRNA was labeled using 3D-Gene® miRNA Labeling kit in accordance with the manufacturer's instructions.



Reference

PMID:30820472
Title:Risk prediction models for dementia constructed by supervised principal component analysis using miRNA expression data
Author:Shigemizu D, Akiyama S, Asanomi Y, Boroevich KA, Sharma A, Tsunoda T, Matsukuma K, Ichikawa M, Sudo H, Takizawa S, Sakurai T, Ozaki K, Ochiya T, Niida S
Journal:Commun Biol. 2019 Feb 25;2:77.
Description:we investigated potential miRNA biomarkers and constructed risk prediction models, based on a supervised principal component analysis (PCA) logistic regression method, according to the subtype of dementia