exRNAdisease

Entry Detail

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General Information

Database ID: exR0201251 RNA Name: hsa-miR-105-5p RNA Type: miRNA Chromosome: chrX Starnd: - Coordinate: Start Site(bp): 152394458 End Site(bp): 152394480 External Links: hsa-miR-105-5p

Disease Information

Disease Name: Mild Cognitive Impairment Disease Category: Other Diseases MeSH ID: D060825 Type: Psychiatry and Psychology Category/Mental Disorders Alias: Cognitive Dysfunction//Cognitive Dysfunctions//Dysfunction, Cognitive//Dysfunctions, Cognitive//Cognitive Impairments//Cognitive Impairment//Impairment, Cognitive//Impairments, Cognitive//Mild Cognitive Impairment//Cognitive Impairment, Mild//Cognitive Impairments, Mild//Impairment, Mild Cognitive//Impairments, Mild Cognitive//Mild Cognitive Impairments//Mild Neurocognitive Disorder//Disorder, Mild Neurocognitive//Disorders, Mild Neurocognitive//Mild Neurocognitive Disorders//Neurocognitive Disorder, Mild//Neurocognitive Disorders, Mild//Cognitive Decline//Cognitive Declines//Decline, Cognitive//Declines, Cognitive//Mental Deterioration//Deterioration, Mental//Deteriorations, Mental//Mental Deteriorations

Expression Detail

GEO ID: GSE120584 Description: Risk prediction models for dementia constructed by supervised principal component analysis using miRNA expression data Experimental Design: Disease vs Control Case Disease Type: Alzheimer's Disease Case Disease SubType: NA Case Sample: Mild Cognitive Impairment Control Sample: Normal Number of Case: 1021 Number of Control: 288 Number of Samples: 1309

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ARPP19 chr15 52547045 52569883 - DNAJB6 chr7 157335381 157417439 + EXTL2 chr1 100872372 100895179 - GTF2H5 chr6 158168350 158199344 + LMBR1 chr7 156668946 156893216 - MAPKAPK2 chr1 206684944 206734283 + MCL1 chr1 150574551 150579738 - MEF2D chr1 156463727 156500779 - NRIP1 chr21 14961235 15065936 - PDPR chr16 70113626 70162537 + PIK3R3 chr1 46040140 46133036 - PYGB chr20 25248085 25298012 + RAB22A chr20 58309715 58367507 + SLC31A1 chr9 113221544 113264492 + miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0000384 chr12 27867712 27877119 + hsa_circ_0000987 chr2 30748452 30756180 + hsa_circ_0001414 chr4 56277780 56284152 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC068768.1 chr12 123262060 123262402 + AC079781.5 chr7 97851688 97972985 - AC145207.5 chr17 81878425 81881106 - CYTOR chr2 87454781 87636740 + EPB41L4A-AS1 chr5 112160526 112164818 + FGD5-AS1 chr3 14920347 14948424 - GAS5 chr1 173858559 173868882 - HCG11 chr6 26521709 26527404 + MALAT1 chr11 65497688 65506516 + MCF2L-AS1 chr13 112967484 112968824 - MIR4435-2HG chr2 111006015 111523376 - NNT-AS1 chr5 43571594 43603230 - NORAD chr20 36045618 36051018 - OIP5-AS1 chr15 41283990 41309737 + SCAMP1-AS1 chr5 78342365 78360507 - XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE120584 Sample Source: Blood Source Fraction: Serum Platform: GPL21263 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2532 Sample treatment protocol: NA RNA Extract protocol: Total RNA was extracted each from 300uL serum samples using 3D-Gene® RNA extraction reagent from liquid sample kit (Toray Industries, Inc.). RNA library preparation protocol: miRNA was labeled using 3D-Gene® miRNA Labeling kit in accordance with the manufacturer's instructions.

Reference

PMID: 30820472 Title: Risk prediction models for dementia constructed by supervised principal component analysis using miRNA expression data Author: Shigemizu D, Akiyama S, Asanomi Y, Boroevich KA, Sharma A, Tsunoda T, Matsukuma K, Ichikawa M, Sudo H, Takizawa S, Sakurai T, Ozaki K, Ochiya T, Niida S Journal: Commun Biol. 2019 Feb 25;2:77. Description: we investigated potential miRNA biomarkers and constructed risk prediction models, based on a supervised principal component analysis (PCA) logistic regression method, according to the subtype of dementia