Entry Detail


General Information

Database ID:exR0201272
RNA Name:hsa-miR-1185-5p
RNA Type:miRNA
Chromosome:chr14
Starnd:+
Coordinate:
Start Site(bp):101044212End Site(bp):101044232
External Links:hsa-miR-1185-5p



Disease Information

Disease Name:Mild Cognitive Impairment
Disease Category:Other Diseases
MeSH ID:D060825
Type:Psychiatry and Psychology Category/Mental Disorders
Alias:Cognitive Dysfunction//Cognitive Dysfunctions//Dysfunction, Cognitive//Dysfunctions, Cognitive//Cognitive Impairments//Cognitive Impairment//Impairment, Cognitive//Impairments, Cognitive//Mild Cognitive Impairment//Cognitive Impairment, Mild//Cognitive Impairments, Mild//Impairment, Mild Cognitive//Impairments, Mild Cognitive//Mild Cognitive Impairments//Mild Neurocognitive Disorder//Disorder, Mild Neurocognitive//Disorders, Mild Neurocognitive//Mild Neurocognitive Disorders//Neurocognitive Disorder, Mild//Neurocognitive Disorders, Mild//Cognitive Decline//Cognitive Declines//Decline, Cognitive//Declines, Cognitive//Mental Deterioration//Deterioration, Mental//Deteriorations, Mental//Mental Deteriorations



Expression Detail

GEO ID:GSE120584
Description:Risk prediction models for dementia constructed by supervised principal component analysis using miRNA expression data
Experimental Design:Disease vs Control
Case Disease Type:Alzheimer's Disease
Case Disease SubType:NA
Case Sample:Mild Cognitive Impairment
Control Sample:Normal
Number of Case:1021
Number of Control:288
Number of Samples:1309





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
CBFA2T3
chr16
88874858
88977207
-
CDKN1B
chr12
12715058
12722369
+
CLDN11
chr3
170418865
170454733
+
EGR1
chr5
138465479
138469303
+
MAPK8IP2
chr22
50600793
50613981
+
PATL1
chr11
59636716
59669037
-
PHTF2
chr7
77798792
77957503
+
miRNA targets:NA
circRNA targets:
circRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa_circ_0000418
chr12
69983264
69985939
+
hsa_circ_0000892
chr19
11941431
12014514
+
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC079781.5
chr7
97851688
97972985
-
AC145207.5
chr17
81878425
81881106
-
AL355488.1
chr1
110370154
110373003
+
EBLN3P
chr9
37079645
37090928
+
NEAT1
chr11
65422774
65445540
+
XIST
chrX
73820649
73852723
-
Display:



Experiment Detail

GEO ID:GSE120584
Sample Source:Blood
Source Fraction:Serum
Platform:GPL21263
Method:Microarray
Num of detected RNA Type:1
Num of detected RNAs of this Type:2532
Sample treatment protocol:NA
RNA Extract protocol:Total RNA was extracted each from 300uL serum samples using 3D-Gene® RNA extraction reagent from liquid sample kit (Toray Industries, Inc.).
RNA library preparation protocol:miRNA was labeled using 3D-Gene® miRNA Labeling kit in accordance with the manufacturer's instructions.



Reference

PMID:30820472
Title:Risk prediction models for dementia constructed by supervised principal component analysis using miRNA expression data
Author:Shigemizu D, Akiyama S, Asanomi Y, Boroevich KA, Sharma A, Tsunoda T, Matsukuma K, Ichikawa M, Sudo H, Takizawa S, Sakurai T, Ozaki K, Ochiya T, Niida S
Journal:Commun Biol. 2019 Feb 25;2:77.
Description:we investigated potential miRNA biomarkers and constructed risk prediction models, based on a supervised principal component analysis (PCA) logistic regression method, according to the subtype of dementia