exRNAdisease

General Information

Database ID:

exR0201287

RNA Name:

hsa-miR-122-5p

RNA Type:

miRNA

Chromosome:

chr18

Starnd:

Coordinate:

Start Site(bp):

58451088

End Site(bp):

58451109

External Links:

Disease Information

Disease Name:	Mild Cognitive Impairment
Disease Category:	Other Diseases
MeSH ID:	D060825
Type:	Psychiatry and Psychology Category/Mental Disorders
Alias:	Cognitive Dysfunction//Cognitive Dysfunctions//Dysfunction, Cognitive//Dysfunctions, Cognitive//Cognitive Impairments//Cognitive Impairment//Impairment, Cognitive//Impairments, Cognitive//Mild Cognitive Impairment//Cognitive Impairment, Mild//Cognitive Impairments, Mild//Impairment, Mild Cognitive//Impairments, Mild Cognitive//Mild Cognitive Impairments//Mild Neurocognitive Disorder//Disorder, Mild Neurocognitive//Disorders, Mild Neurocognitive//Mild Neurocognitive Disorders//Neurocognitive Disorder, Mild//Neurocognitive Disorders, Mild//Cognitive Decline//Cognitive Declines//Decline, Cognitive//Declines, Cognitive//Mental Deterioration//Deterioration, Mental//Deteriorations, Mental//Mental Deteriorations

Expression Detail

GEO ID:	GSE120584
Description:	Risk prediction models for dementia constructed by supervised principal component analysis using miRNA expression data
Experimental Design:	Disease vs Control
Case Disease Type:	Alzheimer's Disease
Case Disease SubType:	NA
Case Sample:	Mild Cognitive Impairment
Control Sample:	Normal
Number of Case:	1021
Number of Control:	288
Number of Samples:	1309

Regulatory Relationship

mRNA targets:

Gene Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
MSI2	chr17	57255851	57684689	+
FAM102A	chr9	127940582	127980989	-
NAGK	chr2	71064344	71079808	+
SPRED2	chr2	65310851	65432637	-
HGSNAT	chr8	43140464	43202855	+
PPDPF	chr20	63520765	63522206	+
SH3GL1	chr19	4360370	4400547	-
SETD1A	chr16	30957754	30984664	+
PEA15	chr1	160205337	160215376	+
C19orf54	chr19	40740856	40751553	-
PIP4K2A	chr10	22534854	22714578	-
RPRD1B	chr20	38033725	38127780	+
CACNG4	chr17	66964707	67033398	+
SOX11	chr2	5692384	5701385	+
IGFBP5	chr2	216672105	216695549	-
RAB1B	chr11	66268590	66277492	+
CSRP1	chr1	201483530	201509456	-
VTI1A	chr10	112446998	112818744	+
ZNF3	chr7	100064033	100082548	-
NHLRC3	chr13	39038306	39050109	+
ZNF614	chr19	52012765	52030240	-
NDOR1	chr9	137205685	137217009	+
ALDOA	chr16	30064164	30070457	+
GRK3	chr22	25564675	25729294	+
C19orf47	chr19	40319536	40348527	-
SLC9A1	chr1	27098809	27166981	-
STK4	chr20	44966479	45080021	+
IER2	chr19	13150411	13154911	+
PRR12	chr19	49591182	49626439	+
KRT7	chr12	52232520	52252186	+

miRNA targets:

circRNA targets:

lncRNA targets:

lncRNA Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
AC021092.1	chr19	44103007	44113183	-
AC103702.1	chr17	48579630	48582259	-
AL358472.3	chr1	153966516	153966930	+
AL645465.1	chr1	244375100	244409592	-
DSCAM-AS1	chr21	40383083	40385358	+
NEAT1	chr11	65422774	65445540	+
SNHG7	chr9	136721366	136728184	-
XIST	chrX	73820649	73852723	-

Display:

Experiment Detail

GEO ID:	GSE120584
Sample Source:	Blood
Source Fraction:	Serum
Platform:	GPL21263
Method:	Microarray
Num of detected RNA Type:	1
Num of detected RNAs of this Type:	2532
Sample treatment protocol:	NA
RNA Extract protocol:	Total RNA was extracted each from 300uL serum samples using 3D-Gene® RNA extraction reagent from liquid sample kit (Toray Industries, Inc.).
RNA library preparation protocol:	miRNA was labeled using 3D-Gene® miRNA Labeling kit in accordance with the manufacturer's instructions.

Reference

PMID:	30820472
Title:	Risk prediction models for dementia constructed by supervised principal component analysis using miRNA expression data
Author:	Shigemizu D, Akiyama S, Asanomi Y, Boroevich KA, Sharma A, Tsunoda T, Matsukuma K, Ichikawa M, Sudo H, Takizawa S, Sakurai T, Ozaki K, Ochiya T, Niida S
Journal:	Commun Biol. 2019 Feb 25;2:77.
Description:	we investigated potential miRNA biomarkers and constructed risk prediction models, based on a supervised principal component analysis (PCA) logistic regression method, according to the subtype of dementia