exRNAdisease

Entry Detail

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General Information

Database ID: exR0201315 RNA Name: hsa-miR-1244 RNA Type: miRNA Chromosome: chr2 Starnd: + Coordinate: Start Site(bp): 231713368 End Site(bp): 231713393 External Links: hsa-miR-1244

Disease Information

Disease Name: Mild Cognitive Impairment Disease Category: Other Diseases MeSH ID: D060825 Type: Psychiatry and Psychology Category/Mental Disorders Alias: Cognitive Dysfunction//Cognitive Dysfunctions//Dysfunction, Cognitive//Dysfunctions, Cognitive//Cognitive Impairments//Cognitive Impairment//Impairment, Cognitive//Impairments, Cognitive//Mild Cognitive Impairment//Cognitive Impairment, Mild//Cognitive Impairments, Mild//Impairment, Mild Cognitive//Impairments, Mild Cognitive//Mild Cognitive Impairments//Mild Neurocognitive Disorder//Disorder, Mild Neurocognitive//Disorders, Mild Neurocognitive//Mild Neurocognitive Disorders//Neurocognitive Disorder, Mild//Neurocognitive Disorders, Mild//Cognitive Decline//Cognitive Declines//Decline, Cognitive//Declines, Cognitive//Mental Deterioration//Deterioration, Mental//Deteriorations, Mental//Mental Deteriorations

Expression Detail

GEO ID: GSE120584 Description: Risk prediction models for dementia constructed by supervised principal component analysis using miRNA expression data Experimental Design: Disease vs Control Case Disease Type: Alzheimer's Disease Case Disease SubType: NA Case Sample: Mild Cognitive Impairment Control Sample: Normal Number of Case: 1021 Number of Control: 288 Number of Samples: 1309

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand RHOA chr3 49359145 49412998 - CPNE3 chr8 86514435 86561498 + KIAA1191 chr5 176346062 176361807 - ZMYM4 chr1 35268709 35422058 + CCT2 chr12 69585426 69601570 + AL590764.2 chrX 71103987 71111575 - RPS5 chr19 58386400 58394806 + UBA2 chr19 34428352 34471251 + CDC42EP3 chr2 37641882 37738468 - EEF1G chr11 62559596 62574086 - GAK chr4 849276 932373 - SPIN1 chr9 88388430 88478694 + ERLIN1 chr10 100150094 100186033 - MT-CO3 chrMT 9207 9990 + HNRNPU chr1 244840638 244864560 - TOLLIP chr11 1274371 1309654 - MLF2 chr12 6747996 6767475 - CCDC18 chr1 93179919 93278730 + MBD3 chr19 1573596 1592865 - RPS2 chr16 1962058 1964841 - PTMA chr2 231706895 231713541 + UBC chr12 124911604 124917368 - OAS2 chr12 112978395 113011723 + APELA chr4 164877178 164898965 + SLC7A1 chr13 29509414 29595688 - ARHGDIB chr12 14942031 14961728 - ARMT1 chr6 151452258 151470101 + AP002990.1 chr11 62559603 62591531 - B2M chr15 44711487 44718877 + RFWD3 chr16 74621399 74666877 - miRNA targets: NA circRNA targets: NA lncRNA targets: NA Display:

Experiment Detail

GEO ID: GSE120584 Sample Source: Blood Source Fraction: Serum Platform: GPL21263 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2532 Sample treatment protocol: NA RNA Extract protocol: Total RNA was extracted each from 300uL serum samples using 3D-Gene® RNA extraction reagent from liquid sample kit (Toray Industries, Inc.). RNA library preparation protocol: miRNA was labeled using 3D-Gene® miRNA Labeling kit in accordance with the manufacturer's instructions.

Reference

PMID: 30820472 Title: Risk prediction models for dementia constructed by supervised principal component analysis using miRNA expression data Author: Shigemizu D, Akiyama S, Asanomi Y, Boroevich KA, Sharma A, Tsunoda T, Matsukuma K, Ichikawa M, Sudo H, Takizawa S, Sakurai T, Ozaki K, Ochiya T, Niida S Journal: Commun Biol. 2019 Feb 25;2:77. Description: we investigated potential miRNA biomarkers and constructed risk prediction models, based on a supervised principal component analysis (PCA) logistic regression method, according to the subtype of dementia