Entry Detail


General Information

Database ID:exR0201322
RNA Name:hsa-miR-1248
RNA Type:miRNA
Chromosome:chr3
Starnd:+
Coordinate:
Start Site(bp):186786675End Site(bp):186786701
External Links:hsa-miR-1248



Disease Information

Disease Name:Mild Cognitive Impairment
Disease Category:Other Diseases
MeSH ID:D060825
Type:Psychiatry and Psychology Category/Mental Disorders
Alias:Cognitive Dysfunction//Cognitive Dysfunctions//Dysfunction, Cognitive//Dysfunctions, Cognitive//Cognitive Impairments//Cognitive Impairment//Impairment, Cognitive//Impairments, Cognitive//Mild Cognitive Impairment//Cognitive Impairment, Mild//Cognitive Impairments, Mild//Impairment, Mild Cognitive//Impairments, Mild Cognitive//Mild Cognitive Impairments//Mild Neurocognitive Disorder//Disorder, Mild Neurocognitive//Disorders, Mild Neurocognitive//Mild Neurocognitive Disorders//Neurocognitive Disorder, Mild//Neurocognitive Disorders, Mild//Cognitive Decline//Cognitive Declines//Decline, Cognitive//Declines, Cognitive//Mental Deterioration//Deterioration, Mental//Deteriorations, Mental//Mental Deteriorations



Expression Detail

GEO ID:GSE120584
Description:Risk prediction models for dementia constructed by supervised principal component analysis using miRNA expression data
Experimental Design:Disease vs Control
Case Disease Type:Alzheimer's Disease
Case Disease SubType:NA
Case Sample:Mild Cognitive Impairment
Control Sample:Normal
Number of Case:1021
Number of Control:288
Number of Samples:1309





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
CHD9
chr16
53055033
53329150
+
ADAM10
chr15
58588809
58749791
-
COA1
chr7
43608456
43729717
-
COMT
chr22
19941733
19969975
+
COPB1
chr11
14443440
14500027
-
EIF3L
chr22
37848868
37889407
+
EIF4A2
chr3
186783205
186789897
+
GSPT1
chr16
11868128
11916082
-
HNRNPA0
chr5
137745651
137754363
-
INO80B
chr2
74455087
74457944
+
INO80B-WBP1
chr2
74455088
74460884
+
KCTD10
chr12
109448655
109477359
-
MRPL13
chr8
120380761
120445402
-
RPS25
chr11
119015712
119018691
-
SEC24B
chr4
109433772
109540896
+
SERINC5
chr5
80111651
80256048
-
TM9SF2
chr13
99446311
99564048
+
miRNA targets:NA
circRNA targets:NA
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
SNHG1
chr11
62851984
62855953
-
Display:



Experiment Detail

GEO ID:GSE120584
Sample Source:Blood
Source Fraction:Serum
Platform:GPL21263
Method:Microarray
Num of detected RNA Type:1
Num of detected RNAs of this Type:2532
Sample treatment protocol:NA
RNA Extract protocol:Total RNA was extracted each from 300uL serum samples using 3D-Gene® RNA extraction reagent from liquid sample kit (Toray Industries, Inc.).
RNA library preparation protocol:miRNA was labeled using 3D-Gene® miRNA Labeling kit in accordance with the manufacturer's instructions.



Reference

PMID:30820472
Title:Risk prediction models for dementia constructed by supervised principal component analysis using miRNA expression data
Author:Shigemizu D, Akiyama S, Asanomi Y, Boroevich KA, Sharma A, Tsunoda T, Matsukuma K, Ichikawa M, Sudo H, Takizawa S, Sakurai T, Ozaki K, Ochiya T, Niida S
Journal:Commun Biol. 2019 Feb 25;2:77.
Description:we investigated potential miRNA biomarkers and constructed risk prediction models, based on a supervised principal component analysis (PCA) logistic regression method, according to the subtype of dementia