exRNAdisease

Entry Detail

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General Information

Database ID: exR0203186 RNA Name: hsa-miR-663a RNA Type: miRNA Chromosome: chr20 Starnd: - Coordinate: Start Site(bp): 26208243 End Site(bp): 26208264 External Links: hsa-miR-663a

Disease Information

Disease Name: Mild Cognitive Impairment Disease Category: Other Diseases MeSH ID: D060825 Type: Psychiatry and Psychology Category/Mental Disorders Alias: Cognitive Dysfunction//Cognitive Dysfunctions//Dysfunction, Cognitive//Dysfunctions, Cognitive//Cognitive Impairments//Cognitive Impairment//Impairment, Cognitive//Impairments, Cognitive//Mild Cognitive Impairment//Cognitive Impairment, Mild//Cognitive Impairments, Mild//Impairment, Mild Cognitive//Impairments, Mild Cognitive//Mild Cognitive Impairments//Mild Neurocognitive Disorder//Disorder, Mild Neurocognitive//Disorders, Mild Neurocognitive//Mild Neurocognitive Disorders//Neurocognitive Disorder, Mild//Neurocognitive Disorders, Mild//Cognitive Decline//Cognitive Declines//Decline, Cognitive//Declines, Cognitive//Mental Deterioration//Deterioration, Mental//Deteriorations, Mental//Mental Deteriorations

Expression Detail

GEO ID: GSE120584 Description: Risk prediction models for dementia constructed by supervised principal component analysis using miRNA expression data Experimental Design: Disease vs Control Case Disease Type: Alzheimer's Disease Case Disease SubType: NA Case Sample: Mild Cognitive Impairment Control Sample: Normal Number of Case: 1021 Number of Control: 288 Number of Samples: 1309

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand COL6A2 chr21 46098112 46132848 + KLC2 chr11 66257294 66267860 + REXO1 chr19 1815248 1848483 - MIDN chr19 1248553 1259140 + STK35 chr20 2101827 2177038 + MIGA2 chr9 129036621 129072082 + SRPRA chr11 126262938 126269144 - KDM2A chr11 67119263 67258082 + JUNB chr19 12791486 12793315 + GNB1 chr1 1785285 1891117 - SYVN1 chr11 65121780 65134533 - SCN1B chr19 35030470 35040449 + SMAD3 chr15 67063763 67195169 + HIF1AN chr10 100529072 100559998 + TNRC6A chr16 24610209 24827632 + ARHGAP1 chr11 46677080 46700619 - ARL8A chr1 202133404 202144743 - PPDPF chr20 63520765 63522206 + KMT5A chr12 123383773 123409353 + RTL8A chrX 135050932 135052196 - SOX12 chr20 325595 330224 + CYB5R3 chr22 42617840 42649392 - PRR12 chr19 49591182 49626439 + CAPN15 chr16 527712 554636 + DMWD chr19 45782947 45792845 - BOC chr3 113211003 113287459 + FAM83H chr8 143723933 143738234 - CLSTN1 chr1 9728926 9823984 - CALR chr19 12938578 12944489 + CMIP chr16 81445170 81711762 + miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC008738.7 chr19 33207129 33207639 + AC020928.2 chr19 36773712 36775908 - AC069281.2 chr7 100572232 100578700 - AC234582.1 chr1 155195004 155205495 + AL137127.1 chr1 19072110 19075511 - AL355075.4 chr14 20343048 20343685 - AL356488.2 chr1 109100193 109100619 + GAS5 chr1 173858559 173868882 - MIR663AHG chr20 26167817 26251546 - NEAT1 chr11 65422774 65445540 + NORAD chr20 36045618 36051018 - SNHG25 chr17 64145970 64146476 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE120584 Sample Source: Blood Source Fraction: Serum Platform: GPL21263 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2532 Sample treatment protocol: NA RNA Extract protocol: Total RNA was extracted each from 300uL serum samples using 3D-Gene® RNA extraction reagent from liquid sample kit (Toray Industries, Inc.). RNA library preparation protocol: miRNA was labeled using 3D-Gene® miRNA Labeling kit in accordance with the manufacturer's instructions.

Reference

PMID: 30820472 Title: Risk prediction models for dementia constructed by supervised principal component analysis using miRNA expression data Author: Shigemizu D, Akiyama S, Asanomi Y, Boroevich KA, Sharma A, Tsunoda T, Matsukuma K, Ichikawa M, Sudo H, Takizawa S, Sakurai T, Ozaki K, Ochiya T, Niida S Journal: Commun Biol. 2019 Feb 25;2:77. Description: we investigated potential miRNA biomarkers and constructed risk prediction models, based on a supervised principal component analysis (PCA) logistic regression method, according to the subtype of dementia