Entry Detail



General Information

Database ID:exR0203798
RNA Name:hsa-miR-1181
RNA Type:miRNA
Chromosome:chr19
Starnd:-
Coordinate:
Start Site(bp):10403505End Site(bp):10403525
External Links:hsa-miR-1181



Disease Information

Disease Name:Vascular Dementia
Disease Category:Nervous System Diseases
MeSH ID:D015140
Type:Diseases Category/Nervous System Diseases
Alias:Dementia, Vascular//Dementias, Vascular//Vascular Dementias//Vascular Dementia//Vascular Dementia, Acute Onset//Acute Onset Vascular Dementia//Subcortical Vascular Dementia//Dementia, Subcortical Vascular//Dementias, Subcortical Vascular//Subcortical Vascular Dementias//Vascular Dementia, Subcortical//Vascular Dementias, Subcortical//Arteriosclerotic Dementia//Arteriosclerotic Dementias//Dementia, Arteriosclerotic//Dementias, Arteriosclerotic//Binswanger Disease//Disease, Binswanger//Chronic Progressive Subcortical Encephalopathy//Binswanger Encephalopathy//Leukoencephalopathy, Subcortical//Leukoencephalopathies, Subcortical//Subcortical Leukoencephalopathies//Encephalopathy, Subcortical Arteriosclerotic//Binswanger's Disease//Binswangers Disease//Disease, Binswanger's//Encephalopathy, Subcortical, Chronic Progressive//Subcortical Encephalopathy, Chronic Progressive//Subcortical Leukoencephalopathy//Subcortical Arteriosclerotic Encephalopathy//Arteriosclerotic Encephalopathy, Subcortical//Arteriosclerotic Encephalopathies, Subcortical//Encephalopathies, Subcortical Arteriosclerotic//Subcortical Arteriosclerotic Encephalopathies//Encephalopathy, Binswanger's//Binswanger's Encephalopathy//Encephalopathy, Binswangers//Encephalopathy, Binswanger//Encephalopathy, Chronic Progressive Subcortical



Expression Detail

GEO ID:GSE120584
Description:Risk prediction models for dementia constructed by supervised principal component analysis using miRNA expression data
Experimental Design:Disease vs Control
Case Disease Type:Alzheimer's Disease
Case Disease SubType:NA
Case Sample:Vascular Dementia
Control Sample:Normal
Number of Case:1021
Number of Control:288
Number of Samples:1309





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
CDC37
chr19
10391133
10420121
-
CHD7
chr8
60678740
60868028
+
IRS2
chr13
109752695
109786583
-
MAZ
chr16
29806106
29811164
+
PIM1
chr6
37170152
37175428
+
RRP1B
chr21
43659560
43696079
+
ZMIZ1
chr10
79068966
79316528
+
CAMK4
chr5
111223653
111494886
+
ELF1
chr13
40931924
41061440
-
GNAS
chr20
58839718
58911192
+
GSPT1
chr16
11868128
11916082
-
HNRNPA0
chr5
137745651
137754363
-
HNRNPUL2
chr11
62712630
62727457
-
HNRNPUL2-BSCL2
chr11
62690275
62727384
-
IMMT
chr2
86143932
86195770
-
MDFIC
chr7
114922154
115019202
+
PRKAA2
chr1
56645314
56715335
+
RAB21
chr12
71754863
71800286
+
RALY
chr20
33993646
34108308
+
SLC4A4
chr4
71062667
71572087
+
SOX1
chr13
112067149
112071706
+
SPINT2
chr19
38244035
38292615
+
TMEFF1
chr9
100473149
100577636
+
TTC3
chr21
37073226
37203112
+
U2AF1
chr21
43092956
43107587
-
U2AF1L5
chr21
6484623
6499261
-
UBE2D2
chr5
139526431
139628434
+
ZNF282
chr7
149195546
149226238
+
miRNA targets:NA
circRNA targets:NA
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC007216.1
chr16
11976851
11977850
-
Display:



Experiment Detail

GEO ID:GSE120584
Sample Source:Blood
Source Fraction:Serum
Platform:GPL21263
Method:Microarray
Num of detected RNA Type:1
Num of detected RNAs of this Type:2532
Sample treatment protocol:NA
RNA Extract protocol:Total RNA was extracted each from 300uL serum samples using 3D-Gene® RNA extraction reagent from liquid sample kit (Toray Industries, Inc.).
RNA library preparation protocol:miRNA was labeled using 3D-Gene® miRNA Labeling kit in accordance with the manufacturer's instructions.



Reference

PMID:30820472
Title:Risk prediction models for dementia constructed by supervised principal component analysis using miRNA expression data
Author:Shigemizu D, Akiyama S, Asanomi Y, Boroevich KA, Sharma A, Tsunoda T, Matsukuma K, Ichikawa M, Sudo H, Takizawa S, Sakurai T, Ozaki K, Ochiya T, Niida S
Journal:Commun Biol. 2019 Feb 25;2:77.
Description:we investigated potential miRNA biomarkers and constructed risk prediction models, based on a supervised principal component analysis (PCA) logistic regression method, according to the subtype of dementia