Entry Detail



General Information

Database ID:exR0266540
RNA Name:hsa-miR-105-5p
RNA Type:miRNA
Chromosome:chrX
Starnd:-
Coordinate:
Start Site(bp):152394458End Site(bp):152394480
External Links:hsa-miR-105-5p



Disease Information

Disease Name:Cystic Fibrosis
Disease Category:Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH ID:D003550
Type:Diseases Category/Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Alias:Fibrosis, Cystic//Mucoviscidosis//Pulmonary Cystic Fibrosis//Cystic Fibrosis, Pulmonary//Pancreatic Cystic Fibrosis//Cystic Fibrosis, Pancreatic//Fibrocystic Disease of Pancreas//Pancreas Fibrocystic Disease//Pancreas Fibrocystic Diseases//Cystic Fibrosis of Pancreas



Expression Detail

GEO ID:GSE135119
Description:Microarray profiling identifies extracellular circulating miRNAs dysregulated in cystic fibrosis
Experimental Design:Disease vs Control
Case Disease Type:Cystic Fibrosis
Case Disease SubType:NA
Case Sample:Cystic Fibrosis
Control Sample:Healthy
Number of Case:5
Number of Control:5
Number of Samples:10





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
ARPP19
chr15
52547045
52569883
-
DNAJB6
chr7
157335381
157417439
+
EXTL2
chr1
100872372
100895179
-
GTF2H5
chr6
158168350
158199344
+
LMBR1
chr7
156668946
156893216
-
MAPKAPK2
chr1
206684944
206734283
+
MCL1
chr1
150574551
150579738
-
MEF2D
chr1
156463727
156500779
-
NRIP1
chr21
14961235
15065936
-
PDPR
chr16
70113626
70162537
+
PIK3R3
chr1
46040140
46133036
-
PYGB
chr20
25248085
25298012
+
RAB22A
chr20
58309715
58367507
+
SLC31A1
chr9
113221544
113264492
+
miRNA targets:NA
circRNA targets:
circRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa_circ_0000384
chr12
27867712
27877119
+
hsa_circ_0000987
chr2
30748452
30756180
+
hsa_circ_0001414
chr4
56277780
56284152
+
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC068768.1
chr12
123262060
123262402
+
AC079781.5
chr7
97851688
97972985
-
AC145207.5
chr17
81878425
81881106
-
CYTOR
chr2
87454781
87636740
+
EPB41L4A-AS1
chr5
112160526
112164818
+
FGD5-AS1
chr3
14920347
14948424
-
GAS5
chr1
173858559
173868882
-
HCG11
chr6
26521709
26527404
+
MALAT1
chr11
65497688
65506516
+
MCF2L-AS1
chr13
112967484
112968824
-
MIR4435-2HG
chr2
111006015
111523376
-
NNT-AS1
chr5
43571594
43603230
-
NORAD
chr20
36045618
36051018
-
OIP5-AS1
chr15
41283990
41309737
+
SCAMP1-AS1
chr5
78342365
78360507
-
XIST
chrX
73820649
73852723
-
Display:



Experiment Detail

GEO ID:GSE135119
Sample Source:Blood
Source Fraction:Plasma
Platform:GPL19117
Method:Microarray
Num of detected RNA Type:1
Num of detected RNAs of this Type:2346
Sample treatment protocol:NA
RNA Extract protocol:Frozen samples; Mixture with Trizol Reagent followed by extraction with RNA Clean and Concentrator kit.
RNA library preparation protocol:Using the Affymetrix GeneChip miRNA 4.0 array, 8ul of plasma from each sample was labelled using FlashTag Biotin RNA Labelling kit.



Reference

PMID:31664087
Title:Microarray profiling identifies extracellular circulating miRNAs dysregulated in cystic fibrosis
Author:Ideozu JE, Zhang X, Rangaraj V, McColley S, Levy H
Journal:Sci Rep. 2019 Oct 29;9(1):15483.
Description:we employed microarray technology to identify aberrantly expressed plasma ECmiRNAs in CF and elucidate the functional relevance of their targets.