exRNAdisease

Entry Detail

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General Information

Database ID: exR0266577 RNA Name: hsa-miR-1224-5p RNA Type: miRNA Chromosome: chr3 Starnd: + Coordinate: Start Site(bp): 184241405 End Site(bp): 184241423 External Links: hsa-miR-1224-5p

Disease Information

Disease Name: Cystic Fibrosis Disease Category: Congenital, Hereditary, and Neonatal Diseases and Abnormalities MeSH ID: D003550 Type: Diseases Category/Congenital, Hereditary, and Neonatal Diseases and Abnormalities Alias: Fibrosis, Cystic//Mucoviscidosis//Pulmonary Cystic Fibrosis//Cystic Fibrosis, Pulmonary//Pancreatic Cystic Fibrosis//Cystic Fibrosis, Pancreatic//Fibrocystic Disease of Pancreas//Pancreas Fibrocystic Disease//Pancreas Fibrocystic Diseases//Cystic Fibrosis of Pancreas

Expression Detail

GEO ID: GSE135119 Description: Microarray profiling identifies extracellular circulating miRNAs dysregulated in cystic fibrosis Experimental Design: Disease vs Control Case Disease Type: Cystic Fibrosis Case Disease SubType: NA Case Sample: Cystic Fibrosis Control Sample: Healthy Number of Case: 5 Number of Control: 5 Number of Samples: 10

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ARF3 chr12 48935723 48957487 - DHCR7 chr11 71428193 71452868 - ZNF621 chr3 40524878 40574685 + SEC14L1 chr17 77088749 77217101 + EMC10 chr19 50476400 50490870 + RACGAP1 chr12 49976923 50033136 - THBD chr20 23045633 23049672 - ENSA chr1 150600851 150629612 - SLC9A3R1 chr17 74748628 74769353 + STK4 chr20 44966479 45080021 + LDOC1 chrX 141111605 141177129 - UBL5 chr19 9827892 9830115 + HOXB8 chr17 48611377 48615292 - ANKRD52 chr12 56237807 56258384 - TRAM2 chr6 52497408 52577060 - RNF157 chr17 76142465 76240493 - STC1 chr8 23841929 23854806 - LMBR1 chr7 156668946 156893216 - CALU chr7 128739292 128773400 + ATP6V1A chr3 113747033 113812056 + KIAA1522 chr1 32741830 32774970 + IKBKB chr8 42271302 42332653 + XPO7 chr8 21919662 22006585 + MIER3 chr5 56919602 56971675 - DYRK1B chr19 39825350 39834201 - TBC1D20 chr20 435480 462543 - MAPKAPK2 chr1 206684944 206734283 + OPA3 chr19 45527427 45602212 - AK2 chr1 33007940 33080996 - FYCO1 chr3 45917899 45995824 - miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC009133.5 chr16 29808679 29812227 + AP000766.1 chr11 107312132 107316271 - NEAT1 chr11 65422774 65445540 + TUG1 chr22 30969245 30979395 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE135119 Sample Source: Blood Source Fraction: Plasma Platform: GPL19117 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2346 Sample treatment protocol: NA RNA Extract protocol: Frozen samples; Mixture with Trizol Reagent followed by extraction with RNA Clean and Concentrator kit. RNA library preparation protocol: Using the Affymetrix GeneChip miRNA 4.0 array, 8ul of plasma from each sample was labelled using FlashTag Biotin RNA Labelling kit.

Reference

PMID: 31664087 Title: Microarray profiling identifies extracellular circulating miRNAs dysregulated in cystic fibrosis Author: Ideozu JE, Zhang X, Rangaraj V, McColley S, Levy H Journal: Sci Rep. 2019 Oct 29;9(1):15483. Description: we employed microarray technology to identify aberrantly expressed plasma ECmiRNAs in CF and elucidate the functional relevance of their targets.