exRNAdisease

Entry Detail

---



General Information

Database ID: exR0266606 RNA Name: hsa-miR-1248 RNA Type: miRNA Chromosome: chr3 Starnd: + Coordinate: Start Site(bp): 186786675 End Site(bp): 186786701 External Links: hsa-miR-1248

Disease Information

Disease Name: Cystic Fibrosis Disease Category: Congenital, Hereditary, and Neonatal Diseases and Abnormalities MeSH ID: D003550 Type: Diseases Category/Congenital, Hereditary, and Neonatal Diseases and Abnormalities Alias: Fibrosis, Cystic//Mucoviscidosis//Pulmonary Cystic Fibrosis//Cystic Fibrosis, Pulmonary//Pancreatic Cystic Fibrosis//Cystic Fibrosis, Pancreatic//Fibrocystic Disease of Pancreas//Pancreas Fibrocystic Disease//Pancreas Fibrocystic Diseases//Cystic Fibrosis of Pancreas

Expression Detail

GEO ID: GSE135119 Description: Microarray profiling identifies extracellular circulating miRNAs dysregulated in cystic fibrosis Experimental Design: Disease vs Control Case Disease Type: Cystic Fibrosis Case Disease SubType: NA Case Sample: Cystic Fibrosis Control Sample: Healthy Number of Case: 5 Number of Control: 5 Number of Samples: 10

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand CHD9 chr16 53055033 53329150 + ADAM10 chr15 58588809 58749791 - COA1 chr7 43608456 43729717 - COMT chr22 19941733 19969975 + COPB1 chr11 14443440 14500027 - EIF3L chr22 37848868 37889407 + EIF4A2 chr3 186783205 186789897 + GSPT1 chr16 11868128 11916082 - HNRNPA0 chr5 137745651 137754363 - INO80B chr2 74455087 74457944 + INO80B-WBP1 chr2 74455088 74460884 + KCTD10 chr12 109448655 109477359 - MRPL13 chr8 120380761 120445402 - RPS25 chr11 119015712 119018691 - SEC24B chr4 109433772 109540896 + SERINC5 chr5 80111651 80256048 - TM9SF2 chr13 99446311 99564048 + miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand SNHG1 chr11 62851984 62855953 - Display:

Experiment Detail

GEO ID: GSE135119 Sample Source: Blood Source Fraction: Plasma Platform: GPL19117 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2346 Sample treatment protocol: NA RNA Extract protocol: Frozen samples; Mixture with Trizol Reagent followed by extraction with RNA Clean and Concentrator kit. RNA library preparation protocol: Using the Affymetrix GeneChip miRNA 4.0 array, 8ul of plasma from each sample was labelled using FlashTag Biotin RNA Labelling kit.

Reference

PMID: 31664087 Title: Microarray profiling identifies extracellular circulating miRNAs dysregulated in cystic fibrosis Author: Ideozu JE, Zhang X, Rangaraj V, McColley S, Levy H Journal: Sci Rep. 2019 Oct 29;9(1):15483. Description: we employed microarray technology to identify aberrantly expressed plasma ECmiRNAs in CF and elucidate the functional relevance of their targets.