exRNAdisease

Entry Detail

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General Information

Database ID: exR0266637 RNA Name: hsa-miR-1270 RNA Type: miRNA Chromosome: chr19 Starnd: - Coordinate: Start Site(bp): 20399320 End Site(bp): 20399342 External Links: hsa-miR-1270

Disease Information

Disease Name: Cystic Fibrosis Disease Category: Congenital, Hereditary, and Neonatal Diseases and Abnormalities MeSH ID: D003550 Type: Diseases Category/Congenital, Hereditary, and Neonatal Diseases and Abnormalities Alias: Fibrosis, Cystic//Mucoviscidosis//Pulmonary Cystic Fibrosis//Cystic Fibrosis, Pulmonary//Pancreatic Cystic Fibrosis//Cystic Fibrosis, Pancreatic//Fibrocystic Disease of Pancreas//Pancreas Fibrocystic Disease//Pancreas Fibrocystic Diseases//Cystic Fibrosis of Pancreas

Expression Detail

GEO ID: GSE135119 Description: Microarray profiling identifies extracellular circulating miRNAs dysregulated in cystic fibrosis Experimental Design: Disease vs Control Case Disease Type: Cystic Fibrosis Case Disease SubType: NA Case Sample: Cystic Fibrosis Control Sample: Healthy Number of Case: 5 Number of Control: 5 Number of Samples: 10

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand MIEF1 chr22 39499432 39518132 + WIPF2 chr17 40219304 40284136 + GBA2 chr9 35736866 35749228 - HIF1AN chr10 100529072 100559998 + TCF12 chr15 56918623 57299281 + CDC42EP2 chr11 65314866 65322417 + LITAF chr16 11547722 11636381 - GRHL2 chr8 101492439 101669726 + PRLR chr5 35048756 35230487 - PATL1 chr11 59636716 59669037 - CACNG4 chr17 66964707 67033398 + ZNF652 chr17 49289206 49362473 - CDC37 chr19 10391133 10420121 - AGFG1 chr2 227472152 227561214 + SMG7 chr1 183472216 183598246 + TRIP6 chr7 100867387 100873454 + FN1 chr2 215360440 215436073 - DCBLD2 chr3 98795941 98901695 - BEND3 chr6 107065182 107115269 - NACC1 chr19 13116862 13141147 + TPM4 chr19 16067021 16103002 + TLNRD1 chr15 81000923 81005788 + SRGAP2 chr1 206203345 206464443 + PITPNA chr17 1517718 1562792 - FAM78A chr9 131258076 131276510 - ATP6V1B2 chr8 20197381 20226819 + VGF chr7 101162509 101165569 - PLAGL2 chr20 32192504 32207743 - PCDH10 chr4 133149294 133208606 + B4GALT5 chr20 49632945 49713878 - miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0001247 chr22 46125304 46136418 + hsa_circ_0001159 chr20 40161688 40179999 - hsa_circ_0000471 chr13 33091993 33101669 - hsa_circ_0001666 chr6 170626457 170639638 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC239868.1 chr1 149861271 149862504 + AC245033.4 chr15 82533175 82540008 - AP000233.2 chr21 25095022 25103670 + MALAT1 chr11 65497688 65506516 + NEAT1 chr11 65422774 65445540 + NORAD chr20 36045618 36051018 - NR2F2-AS1 chr15 96110040 96327361 - OIP5-AS1 chr15 41283990 41309737 + SNHG12 chr1 28578538 28583132 - SNHG8 chr4 118278709 118285316 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE135119 Sample Source: Blood Source Fraction: Plasma Platform: GPL19117 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2346 Sample treatment protocol: NA RNA Extract protocol: Frozen samples; Mixture with Trizol Reagent followed by extraction with RNA Clean and Concentrator kit. RNA library preparation protocol: Using the Affymetrix GeneChip miRNA 4.0 array, 8ul of plasma from each sample was labelled using FlashTag Biotin RNA Labelling kit.

Reference

PMID: 31664087 Title: Microarray profiling identifies extracellular circulating miRNAs dysregulated in cystic fibrosis Author: Ideozu JE, Zhang X, Rangaraj V, McColley S, Levy H Journal: Sci Rep. 2019 Oct 29;9(1):15483. Description: we employed microarray technology to identify aberrantly expressed plasma ECmiRNAs in CF and elucidate the functional relevance of their targets.